Health professionals and users of dietary supplements should be educated better on the use of these products in order to make the supplement use safe, controlled and rational.

A B S T R A C TThe quality of employees' work in the tourism industry depends primarily on their job satisfaction. This has directed the subject of the research in this paper to examine the impact of employee satisfaction on tourist satisfaction with the services of spa tourism in the Republic of Serbia. Research was conducted using the survey method, the questionnaire technique, in Lukovska Spa, based on a sample of 125 respondents, of which 55 were employees and 70 tourists / guests in hotels "Jelak" and "Kopaonik". The most important finding of the research is related to the correlation between the employee satisfaction and the tourist satisfaction with the quality of service in Lukovska Spa, which confirmed the hypothesis of the direct and positive impact of employee satisfaction on the tourist satisfaction with the quality of services. Employee satisfaction has a positive impact on the quality of the service, which directly affects the tourist satisfaction with the quality of the services provided.

Cultural heritage is an authentic and unrepeatable resource. Cultural, economic, political, and ecological facts evaluate its observations, both qualitatively and quantitatively. Therefore, we won't exaggerate if we say that cultural heritage should have the status of a strategic resource. In this way, both cultural revitalization and general sustainable development are based on it. The scope and dynamics of conducting complex activities, which unite the restoration, conservation, renovation, revitalization, sanitation, and presentation of protected cultural heritage, condition the preservation and promotion of categorized and immovable cultural heritage. The creation of cultural-historical heritage of Sremski Karlovci and its gradual and systematic tourist valorization are the basis for deepening our understanding of its potential. This potential is based on the effective politics of heritage management. It can become an experience and provide pointers for sustainable development. Establishing a correlation between the most important attractions and multipliers supports the necessary move from the multidisciplinary approach to tourism development to an interdisciplinary one. This approach should help one shape and achieve the goals of the development of culture and tourism by relying on cross-sector and interdepartmental connections, and continued cooperation. Kulturno-istorijski resursi kao generatori turističkog razvoja Sremskih KarlovacaSažetak: Kulturno nasleđe predstavlja autentičan i neponovljiv resurs čije se refleksije kvalitativno i kvantitativno vrednuju kulturnim, ekonomskim, političkim i ekološkim činjenicama. Stoga nije preambiciozno ako kažemo da kulturno nasleđe treba da ima status strateškog resursa, na kojem se zasniva kulturna samorevitalizacija, ali i sveukupni održivi razvoj. Očuvanje i promocija kategorizovanog nepokretnog kulturnog nasleđa uslovljeni su obimom i dinamikom izvođenja složenih zahvata koji integrišu obnovu, konzervaciju, restauraciju, revitalizaciju, sanaciju i adaptaciju zaštićenog kulturnog nasleđa. Mapiranje kulturno-istorijskog nasleđa Sremskih Karlovaca i njegova postupna i sistematična turistička valorizacija predstavljaju bazičnu platformu za razumevanje i produbljivanje svesti o potencijalu koji, na bazi efikasnih politika upravljanja nasleđem, može postati iskustvo i putokaz za održivi razvoj. Uspostavljajući korelaciju između najvažnijih resursnih atrakcija i multiplikatora, protežira se neophodnost iskoraka sa multidisciplinarnog pristupa razvoju turizma na interdisciplinarnu platformu. Takav pristup trebalo bi da obezbedi integrisano * branislav.sancanin@famns.edu.rs Sančanin, B. et al. -Cultural-historical resources as initiators of tourism development in Sremski Karlovci -Hotel and Tourism Management, 2019, Vol. 7, No. 2: 77-85. 78 definisanje i realizaciju ciljeva razvoja kulture i turizma, kroz međusektorsko i međuresorno povezivanje i kontinuiranu saradnju.

It is known that the long-standing political and economic environment in our country has stopped the development of tourism and that the quality and diverse resource base of the Republic of Serbia is not sufficiently utilized. The offer of Serbian tourism products, spontaneously developed for the needs of domestic tourism, is not able to respond to the contemporary trends of the international tourist market, because there have been major changes in the market according to which the Republic of Serbia has not adapted its tourist offer. This has directed the subject of research in this paper to determine the achieved level of tourism development in the Republic of Serbia. Based on the new demands of modern tourists and global trends in tourism, the Republic of Serbia has the opportunity to capitalize its current position, to form a tourist offer and to achieve significant growth in the tourism sector and thereby provide a place on the world tourist map.

Background/Aims: Energy homeostasis is a balance between energy intake and energy expenditure. Leptin and ghrelin are two orexitropic hormones with opposite effect on energy homeostasis. We investigated fasting ghrelin and leptin levels in children with different nutritional conditions. Methods: In 30 obese children of both sexes, aged from 6 to 17.67 years (mean 13.04 ?2.95), fasting ghrelin and leptin levels were measured, along with auxological assessment and pubertal staging. These results were analyzed and compared with the same parameters of 33 lean and 25 undernourished (UN) children. Results: Mean ghrelin/BM (body mass) level was the lowest in obese children, (21,75?12,60 pg/ml/kg) with high significance in comparison with lean and UN subjets. Mean leptin/kg level of 56.12?96.94 in obese, was significantly higher than in lean and UN children (p<0.01 and p<0.001 respectively). Ghrelin and leptin levels showed different profiles in obese, lean and UN children. An inverse relationship was discovered between study groups in ghrelin/leptin and leptin/ghrelin ratios. Conclusion: Obese children, compared to other children, demonstrate significantly higher values of leptin, and UN children demonstrate significantly higher values of ghrelin per kilogram of body weight. The results also illustrate the inverse ratio of ghrelin and leptin, which has been demonstrated as a clinically reliable indicant of the status of obesity or undernutrition in children, with significant implications concerning rather large variations in the concentration of these hormones not only with body mass, but also with age of the children. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 31060]

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Smoking is a burning healthcare and economy issue, especially in underdeveloped countries. The aim of this study was to determine the number of smokers among elementary school students in Montenegro and to assess the correlates of tobacco use. The study was done in 2003 using the World Health Organization Global Youth Tobacco Survey. Our data showed that children as young as ten years smoked. There were 3.6 % permanent smokers and one in three students (30.6 %) experimented with smoking. More than two thirds who smoked agreed that they should quit smoking, and three fourths tried to quit. This study has also shown that children talk too little about smoking in schools and are exposed to passive smoking at home and elsewhere. Activities to solve the elementary school smoking problem should include preventive programs to be introduced into regular school curricula because this is the only way to address the issue properly. In addition, legislation prohibiting indoor tobacco smoking should be implemented rigorously to protect children from passive smoking in public places.

Large defects of abdominal wall (greater than 8 cm in diameter) related to different cause, are still difficult problem of modern surgery. The best results in order to obtain safe and permanent anatomical and functional abdominal wall integrity are reached by autogenous dermal and synthetic grafts. Controversies concerning quality of these procedures are still presents. Our work is based on two equal experimental groups of 20 Vister rats each, with large artificial abdominal wall defects: one treated with autogenous dermal graft, another with synthetic Mersilene mesh graft. The animals from both groups were sacrificed in previous planned time intervals (3rd, 7th, 14th and 48th days). Afterwards detailed microscopic and gross examination of abdominal wall reparation and quality of reconstructed abdominal wall defects had been performed. According to our results both methods are easy to be performed and safety surgical procedures. Overestimated usage of synthetic grafts should be diminished because of advantages of autologous dermal graft--availability, substitution of firmly fibrosis tissue and endurance against infection.