The following is a summary of one of the papers presented at a Joint Meeting of the Midlands Region and the Chromatography and Electrophoresis Group held on May 16th, 1984, at the University of Technology, Loughborough. A summary of the other paper, by M. B. Masters, appeared under the Recent Developments and Applications in Ion Chromatography meeting in the September issue (p. 322).
Documentary evidence of the need to define the term "microbore" HPLC was first presented in tabular form by the author in 1982.1 This is shown below (Table I) and a study of it led us to the following two conclusions: (1) none of the nine names currently used to describe columns of small inner diameter is in fact specific and (2) a possible solution to the nomenclature problem is to give the actual inner diameter of the column, measured in micrometres, in parentheses immediately following the general description of the column.Current interest in "microbore" HPLC, that is, HPLC using columns of inner diameter 2 mm or less, stems from the considerable list of benefits that would be expected to follow if columns of small inner diameter were to be generally employed. This list is as follows: (a) higher mass sensitivity arising from the smaller sample size; (b) lower solvent consumption due to the lower eluent flow-rates; (c) improved ability to interface with mass spectrometers, again due to lower eluent flow-rates; (d) better separation
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