Objective To study the effect of iron supplementation on pregnancy outcome in pregnant women with haemoglobin (Hb) ‡13.2 g/dl.Design A randomised, double-blind, placebo-controlled trial.Setting Routine health services.Population Seven hundred and twenty-seven pregnant women with Hb ‡13.2 g/dl in the early stage of the second trimester.Methods Each woman took one tablet of 50 mg of ferrous sulphate daily in the case group (n = 370) or placebo in the control group (n = 357) throughout pregnancy.Main outcome measures Pregnancy outcome.Results While there were no significant differences in demographic and obstetric characteristics between the two groups before any intervention, small-for- Conclusions Our finding proves that routine iron supplementation in nonanaemic women is not rational and may be harmful.Keywords Iron supplementation, nonanaemic women, pregnancy outcome.Please cite this paper as: Ziaei S, Norrozi M, Faghihzadeh S, Jafarbegloo E. A randomised placebo-controlled trial to determine the effect of iron supplementation on pregnancy outcome in pregnant women with haemoglobin ‡ 13.2 g/dl. BJOG 2007;114:684-688.

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