A Randomized Placebo-controlled Trial to Determine the Effect of Iron Supplementation on Pregnancy Outcome in Pregnant Women With Hemoglobin &gt;13.2 g/dL

Ziaei, Saeideh; Norrozi, Mansoreh; Faghihzadeh, Soghrat; Jafarbegloo, Esmat

doi:10.1097/01.ogx.0000279312.87358.26

Cited by 3 publications

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“…Although controlled trials of iron supplementation during pregnancy have consistently demonstrated positive effects on maternal iron status at delivery [11], they have not demonstrated reductions in risks associated with maternal anemia such as preterm delivery and low birth weight [12]. In our previous study, which was carried out with a large population of pregnant women whose hemoglobin concentration was 13.2 g/dL or greater between the 13th and the 18th week of pregnancy, we found that supplementation had a negative effect on pregnancy outcome and determined that iron supplementation should not be recommended to these women [9]. We chose 13.2 g/dL based on a study by Murphy and colleagues [13], who found that complications of pregnancy increased from this threshold on.…”

Section: Discussionmentioning

confidence: 85%

“…In our previous study, which was carried out with a large population of pregnant women whose hemoglobin concentration was 13.2 g/dL or greater between the 13th and the 18th week of pregnancy, we found that supplementation had a negative effect on pregnancy outcome and determined that iron supplementation should not be recommended to these women [9]. We chose 13.2 g/dL based on a study by Murphy and colleagues [13], who found that complications of pregnancy increased from this threshold on.…”

Section: Discussionmentioning

confidence: 95%

“…In our previous study, we found that women who received iron supplementation although they had a high (≥ 13.2 g/dL) hemoglobin concentration in the early stage of the second trimester of pregnancy were at increased risk for pregnancy‐induced hypertensive disorder, and that their fetus was at increased risk of being born small for gestational age. For this reason, we do not recommend iron supplementation for all pregnant women [9].…”

Section: Introductionmentioning

confidence: 98%

See 2 more Smart Citations

Iron status markers in nonanemic pregnant women with and without iron supplementation

Ziaei

Mehrnia

Faghihzadeh

2007

Intl J Gynecology & Obste

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 98%

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Iron status markers in nonanemic pregnant women with and without iron supplementation

Ziaei

Mehrnia

Faghihzadeh

2007

Intl J Gynecology & Obste

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“…En conclusión, los resultados a la fecha no apoyan la necesidad de un suplemento de hierro de forma generalizada a toda gestante. Los resultados igualmente demuestran que la suplementación con hierro a las gestantes en la altura debería ser evitada si es que la anemia no está claramente demostrada, tal como ha sido recomendada por otros autores para otras poblaciones a nivel del mar con Hb ≥ 13,2 g/dL (93) .…”

Section: Hemoglobina Materna Y Resultado Ad-verso Materno Y Perinatal Del Embarazounclassified

Hierro, anemia y eritrocitosis en gestantes de la altura: riesgo en la madre y el recién nacido

Gonzáles

Gonzales

2013

Rev peru ginecol obstet.

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El hierro es un micronutriente necesario para la salud, pero su exceso es dañino. El organismo tiene una alta capacidad de almacenar y reutilizar el hierro corporal, de tal manera que su requerimiento es mínimo (1 a 2 mg absorbido/día). La hepcidina, una hormona producida en el hígado, cumple un rol importante en la homeostasis del hierro inhibiendo a la proteína transportadora de hierro y disminuyendo la absorción de hierro. La anemia materna por deficiencia de hierro se constituye en un problema de salud pública cuando es de magnitud moderada (7 a <9 g/dL) y severa (Hb <7 g/dL), incrementando el riesgo de morbi-mortalidad materna y del neonato. Igualmente, se ha demostrado que niveles altos de hemoglobina en la gestante afecta a la madre y al neonato. En el Perú existe el Programa Nacional de Suplemento con hierro a todas las gestantes, sean o no anémicas. Las evidencias científicas muestran que valores de hemoglobina entre 9 y 10,5 g/dL son óptimas para el mejor crecimiento del feto y que el tratamiento con suplemento de hierro de gestantes no anémicas aumenta los niveles de hemoglobina, el estrés oxidativo y tiene efectos adversos en el recién nacido. Dado que en muchas poblaciones en la altura aumentan los niveles de hemoglobina, se ha sugerido corregir el punto de corte de la Hb para definir anemia. Diversos estudios han mostrado que no sería necesario corregir el punto de corte usado a nivel del mar. En conclusión, los resultados de los estudios no apoyan la necesidad de un suplemento de hierro de forma generalizada a toda gestante. La suplementación con hierro a las gestantes en la altura debería ser evitada si es que la anemia no está claramente demostrada. Se recomienda en cada población de altitud establecer el nivel de anemia y el estatus del hierro corporal, antes de decidir dar un tratamiento con suplemento de hierro.Palabras clave: Anemia materna, eritrocitosis materna, hepcidina, altura, hierro.

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“…[80][81][82] In pregnancy, excessive iron supplements might expose women to increased oxidative stress, lipid peroxidation, and pregnancyinduced hypertensive disorders. [83][84][85] Two recent meta-analysis suggested that high iron status might contribute to increase the risk of gestational diabetes, possibly mediated by iron oxidative stress. 86,87 The overproduction of reactive oxygen species can represent an important mediator of damage to cell structures, including lipids, proteins and DNA.…”

Section: Ironmentioning

confidence: 99%

Micronutrient supplementation in pregnancy: Who, what and how much?

et al. 2018

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Pregnancy represents a period of major physiological and metabolic change, aiming to ensure proper fetal growth and development, as well as maternal preservation. This review focuses on maternal nutrition, and particularly on micronutrient deficiencies and supplementation during pregnancy. Nutrient deficiencies and consequences in pregnant women are presented, with an overview of current recommendations for dietary supplementation in pregnancy, even considering the risk of micronutrient overload. Appropriate universal supplementation and prophylaxis/treatment of nutritional needs currently appear to be the most cost-effective goal in low-income countries, thus ensuring adequate intake of key elements including folate, iron, calcium, vitamin D and A. In high-income countries, a proper nutritional assessment and counselling should be mandatory in obstetric care in order to normalize pregestational body mass index, choose a healthy dietary pattern and evaluate the risk of deficiencies.

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A Randomized Placebo-controlled Trial to Determine the Effect of Iron Supplementation on Pregnancy Outcome in Pregnant Women With Hemoglobin >13.2 g/dL

Cited by 3 publications

References 0 publications

Iron status markers in nonanemic pregnant women with and without iron supplementation

Iron status markers in nonanemic pregnant women with and without iron supplementation

Hierro, anemia y eritrocitosis en gestantes de la altura: riesgo en la madre y el recién nacido

Micronutrient supplementation in pregnancy: Who, what and how much?

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