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The synthesis of several new compounds containing an ethanolamine moiety are reported, of which two exhibit promising antimicrobial activity (at the 6 μM level).

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Synthesis of Quinolines, 2-Quinolones, Phenanthridines, and 6(5H)-Phenanthridinones via Palladium[0]-Mediated Ullmann Cross-Coupling of 1-Bromo-2-nitroarenes with β-Halo-enals, enones, or -esters. -A simple, economical, and effective two-step procedure for the synthesis of various substituted title compounds is demonstrated. In some cases, substantial amount of by-products arising from homo-coupling of the corresponding bromoketones is found. -(BANWELL*, M. G.; LUPTON, D. W.; MA, X.; RENNER, J.; SYDNES, M. O.; Org.

A large number of diversely functionalized analogs of the bioactive natural products neocryptolepine and isocryptolepine have been prepared from a series of 3-bromoquinoline derivatives. The neocryptolepines were obtained by a Pd 0catalyzed CÀ C bond coupling followed by CÀ N bond formation in yields up to 80 %, whereas the indoloquinolines were prepared by a Suzuki-Miyaura cross-coupling followed by azidation-photochemical cyclization in yields ranging from traces to 95 % yield.

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Solvent accounts for majority of the waste derived from synthetic transformations. This implies that by making changes to the solvent used by either switching to greener options, reducing the volume of solvent used, or even better avoiding the use of solvent totally will have a positive impact on the environment. Herein, the focus will be on the use of bio-based-green-solvents in C-C crosscoupling reactions highlighting the recent developments in this field of research. Emphasis in this review will be placed on developments obtained for Mizoroki-Heck, Hiyama, Stille, and Suzuki- Miyaura cross-couplings. For these cross-coupling reactions, good reaction conditions utilizing green solvents are now available.