The Use of Microwave For One-pot Reductive Amination

Sydnes, Magne O.

doi:10.2174/2213346102666151028205051

Cited by 5 publications

(2 citation statements)

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“…9 Sodium borohydride (NaBH 4 ) is a safe, green, environment-friendly and inexpensive reducing agent, so it has been the conclusive choice for the direct reductive amination process and has been used with various catalysts. 12 However, its application is restricted, in view of the fact that it is accomplished to reduce other reducible functional groups in the molecule.…”

Section: Introductionmentioning

confidence: 99%

One-pot Reductive Amination of Carbonyl Compounds with NaBH 4 -B(OSO 3 H) 3 /SiO 2 in Acetonitrile and in Solvent-free Condition

Hamadi

Javadi

2017

J Chem Sci

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An efficient one-pot procedure for the direct reductive amination of aldehyde and ketones was achieved in the presence of sodium borohydride by using B(OSO 3 H) 3 /SiO 2 (SBSA) as the reusable solid catalyst in acetonitrile and solvent-free conditions. Both aromatic and aliphatic aldehyde reacted well to give the corresponding amines in excellent yields. All the products are known and well-characterized. The catalyst is recoverable and could be easily recycled by filtration and reused several times without any significant loss of its activity. SBSA acts as a dual Brønsted/Lewis acid that is an air-stable and cost-effective solid acid.

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Section: Introductionmentioning

confidence: 99%

One-pot Reductive Amination of Carbonyl Compounds with NaBH 4 -B(OSO 3 H) 3 /SiO 2 in Acetonitrile and in Solvent-free Condition

Hamadi

Javadi

2017

J Chem Sci

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“…[1][2][3][4][5][6][7][8][9][10][11] In industrial processes, multi-steps are required to synthesise most ne chemicals, and as a result, purication processes during each reaction step cause the loss of products and production of undesired chemical wastes. [1][2][3][4][5][6][7][8][9][10][11] In industrial processes, multi-steps are required to synthesise most ne chemicals, and as a result, purication processes during each reaction step cause the loss of products and production of undesired chemical wastes.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and bifunctional catalysis of metal nanoparticle-loaded periodic mesoporous organosilicas modified with amino groups

et al. 2015

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The present article describes the development of a periodic mesoporous organosilica (PMO)-based bifunctional catalyst that includes both oxidative and base catalytic activities. Periodic mesoporous ethylenesilica (PME) was selected as a catalyst support and modified with ethylenediamine through epoxidation of bridging ethylene moieties and the following nucleophilic addition in order to construct base sites. FT-IR measurements for the resulting material, PME-ED, reveal the successful introduction of amino groups into the bridging ethylene moieties. PME-ED can promote Knoevenagel condensation between benzaldehyde and various active methylene compounds as a solid base catalyst. The scope of applicable active methylene compounds in this catalytic system shows the base strength of PME-ED, in which a proton can be abstracted from diethyl malonate (pK a : 16.4) but not from benzyl cyanide (pK a : 21.9). Moreover, the generation of bifunctional catalytic properties to promote a one-pot tandem reaction consisting of alcohol oxidation and Knoevenagel condensation is realised by loading of Au nanoparticles within PME-ED. This catalyst design methodology can be also extended to developing another bifunctional catalyst that is composed of Pd nanoparticles and PME modified with N,Ndimethylethylenediamine in order to promote a Tsuji-Trost reaction.

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Scandium-catalysed intermolecular hydroaminoalkylation of olefins with aliphatic tertiary amines

et al. 2016

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The Use of Microwave For One-pot Reductive Amination

Cited by 5 publications

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One-pot Reductive Amination of Carbonyl Compounds with NaBH 4 -B(OSO 3 H) 3 /SiO 2 in Acetonitrile and in Solvent-free Condition

One-pot Reductive Amination of Carbonyl Compounds with NaBH 4 -B(OSO 3 H) 3 /SiO 2 in Acetonitrile and in Solvent-free Condition

Synthesis and bifunctional catalysis of metal nanoparticle-loaded periodic mesoporous organosilicas modified with amino groups

Scandium-catalysed intermolecular hydroaminoalkylation of olefins with aliphatic tertiary amines

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