The synthesis of several new compounds containing an ethanolamine moiety are reported, of which two exhibit promising antimicrobial activity (at the 6 μM level).
As a strategy to
inactivate antimicrobial agents after use, we
designed a range of ethanolamine derivatives where four of them possessed
interesting activity. The ethanolamine moiety facilitates photodecomposition,
which in a potential drug will take place after use. Herein, the synthetic
preparation of these compounds and the mechanism of photoinactivation
are described.
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