As one type of pharmacological analyses of a hot water extract of Bamboo Grass (Sasa Albomargrita) (Folin solution), the effect of the extract on gastric secretion was studied in the rat. Folin solution was separated into Lots 1 and 2: Lot 1 was extracted by hot water while Lot 2 was extracted by hot water in a pressure oven. The main component in both Lot 1 and 2 was confirmed as a polysaccharide, the molecular weight of which was less than 5,000. The folin solution has a marked stimulatory effect on gastric acid secretion in the rat.Male Donryu strain rats, 180-210 g, were deprived of all solid food for 24 hr but had free access to water. The pylorus was ligated under ether anesthesia according to the standard method by Shay et al.(1). Folin solution, either Lot 1 or 2, was given orally or intraduodenally 10 min after pylorus ligation in doses of 0.5, 1.0 or 1.5 g/kg; each volume was 0.5, 1.0 or 1.5 ml/200 g of body weight, respectively. Four hr after the administration of Folin solution, during which time no food and water was provided, the animals were sacrificed under ether anesthesia and the gastric contents were collected. The control animals were given the same amount of saline solution either orally or intraduodenally.After centrifugation, samples were analyzed for volume and titrated with 0
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