Pharmacological Studies on Bupleurum falcatum L. II. : Antiinflammatory and Other Pharmacological Actions of Crude Saikosides

Shim

Biological & Pharmaceutical Bulletin

et al. 2009

Many studies have shown that Bupleurum falcatum (BF), which is widely used in the treatment of various psychosomatic diseases in traditional Oriental medicine, is an effective therapeutic intervention for memory impairment. The purpose of this study was to examine the effect of BF on stress-induced alterations in learning and memory in rats using the Morris water maze (MWM) and elevated plus maze (EPM) behavioral tests. In addition, we examined the effects of BF treatment on the cholinergic system, as indicated by changes in neuronal choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) immunoreactivity in the hippocampus. BF (150, 300, or 600 mg/kg) was administered orally 30 min before exposure to repeated immobilization (IMO) stress (4 h/d for 14 d). The BF treatment produced a significant improvement in escape latency (time required to find the platform) in the MWM, and it also produced an anxiolytic-like effect in the EPM. Consistent with the behavioral data, BF treatment significantly attenuated the IMO stress-induced loss of cholinergic immunoreactivity in the hippocampus. These findings indicate that BF has a protective effect against repeated IMO stressinduced neuronal and cognitive impairments, and they suggest that BF may be useful in the treatment of stressinduced memory impairment.

mentioning

confidence: 99%

Effect of <i>Bupleurum falcatum</i> on the Stress-Induced Impairment of Spatial Working Memory in Rats

Shim

Biological & Pharmaceutical Bulletin

et al. 2009

“…B. falcatum has been used as a traditional medicine throughout the World, and is one of the major components of herbal treatments, and is used in the treatment of many psychosomatic disorders, including stress and mental illness [107]. The major pharmaceutical constituents of B. falcatum, including saikosaponin-a, saikosaponin-c, and saikosaponin-d aglycones, are located in the roots [108]. B. falcatum has been proven to be effective in enhancing cognitive function in recent pharmacological studies.…”

Section: Miscellaneous Tkm Plantsmentioning

confidence: 99%

Traditional Korean East Asian Medicines and Herbal Formulations for Cognitive Impairment

Kumar

Song

et al. 2013

Molecules

Abstract:Hanbang, the Traditional Korean Medicine (TKM), is an inseparable component of Korean culture both within the country, and further afield. Korean traditional herbs have been used medicinally to treat sickness and injury for thousands of years. Oriental medicine reflects our ancestor's wisdom and experience, and as the elderly population in Korea is rapidly increasing, so is the importance of their health problems. The proportion of the population who are over 65 years of age is expected to increase to 24.3% by 2031. Cognitive impairment is common with increasing age, and efforts are made to retain and restore the cognition ability of the elderly. Herbal materials have been considered for this purpose because of their low adverse effects and their cognitive-enhancing or anti-dementia activities. Herbal materials are reported to contain several active compounds that have effects on cognitive function. Here, we enumerate evidence linking TKMs which have shown benefits in memory improvements. Moreover, we have also listed Korean herbal formulations which have been the subject of scientific reports relating to memory improvement.

J of Separation Science

“…It has been used widely for the treatment of chronic hepatitis [1,2], inflammatory diseases [3,4], ulcer of digestive organs [5,6], tumor [7][8][9] and immunomodulatory activities [10,11]. Saikosaponins are the main active components of B. falcatum, which are directly related to many pharmacology actions [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Optimization of supercritical fluid extraction of saikosaponins from Bupleurum falcatum with orthogonal array design

Sun

Wang

et al. 2010

Supercritical fluid extraction (SFE) was used to extract saikosaponins a, c and d from the root of Bupleurum falcatum. An orthogonal array design L(9)(3)(4) was employed as a chemometric method for the optimization of the SFE conditions. The effects of four factors including pressure (30-40 MPa), temperature (40-50 degrees C), ethanol concentration (60-100%) and time (2.5-3.5 h) on the yields of saikosaponins were investigated by a preparative SFE system in the SFE mode. Under the optimized conditions, namely 35 MPa of pressure, 45 degrees C of temperature, 80% of ethanol concentration and 3.0 h of time, the yields of saikosaponin c, saikosaponin a, saikosaponin d, total saikosaponins and SFE extract were 0.16, 0.12, 0.96, 1.24 and 16.48 mg/g, respectively. Determinations of the saikosaponins were performed by HPLC.