Pharmacological Studies on Bamboo Grass. IV. Toxicological and Pharmacological Effects of the Extract (FIII) obtained from Sasa albomarginata MAKINO et SHIBATA

Shibata, Madoka; Fojii, M; Yamaguchi, Rikii

doi:10.1248/yakushi1947.99.6_663

Cited by 17 publications

(9 citation statements)

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“…Several researches have reported the pharmacologic effects of the leave extracts from Sasa , a kind of common bamboo grass in Asia, including antitoxic, anti‐inflammatory, anticancer and prevention of cardiovascular diseases (Shibata et al . , , , ; Tripathi et al . ; Sakai et al .…”

Section: Introductionmentioning

confidence: 99%

“…Bamboo grass possessing developed underground whip and dense leaf has the advantages of rapid growth, lush foliage and easy collection. Several researches have reported the pharmacologic effects of the leave extracts from Sasa, a kind of common bamboo grass in Asia, including antitoxic, anti-inflammatory, anticancer and prevention of cardiovascular diseases (Shibata et al 1975(Shibata et al , 1976(Shibata et al , 1978(Shibata et al , 1979Tripathi et al 2006;Sakai et al 2008). However, few investigations have been carried out of other bamboo grass for their biological analysis and pharmacologic effects.…”

Section: Introductionmentioning

confidence: 99%

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Influence of Harvest Season and Drying Method on the Antioxidant Activity and Active Compounds of Two Bamboo Grass Leaves

Zhang

et al. 2013

Journal of Food Processing and Preservation

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Changes of the antioxidant activity and active compounds content from two bamboo grass leaves, namely, Pleioblastus kongosanensis f. aureostriatus and Shibataea chinensis, as affected by different harvest season and drying methods were investigated and the main compounds that influence the antioxidant activity of two bamboo grasses were analyzed by principal component analysis. The content of total flavonoids, phenolics, triterpenoids and eight active compounds, i.e., orientin, isoorientin, vitexin, homovitexin and p‐coumaric acid, chlorogenic acid, caffeic acid, ferulic acid were determined by UV‐spectrophotometer and reverse phase high performance liquid chromatography synchronously, respectively, while antioxidant activity was measured using diphenyl‐2‐picryl‐ hydrazyl and ferric reducing antioxidant power methods. Both bamboo grasses leaves showed the highest level of total active components and antioxidant activity in winter. Different drying methods also affected the active compounds. Lyophilization, followed by vacuum drying and microwave oven drying, was the most suitable method for keeping active components, yet considering the energy consuming, microwave oven drying was recommended for bamboo grass leaves. Practical Applications Bamboo leaves, with excellent free radical scavenging, antioxidation, antibacterial, antiviral, enhancing immunity and other biological effectiveness, have been used for over 1,000 years in Asia as health food material and folk medicine. Bamboo grasses leaves, with advantages of rapid growth, lush foliage and easy collection, were a kind of new potential leafy bamboo grove. In order to improve the comprehensive utilization of leaves and exploit them more scientifically and efficiently, the present study investigated the changes of total phenolics, flavonoids, triterpenoid and eight active compounds content as well as antioxidant actives in leaves in accordance with seasonal variation and different drying methods. The results showed the optimum season for bamboo grass leaves harvest is at winter, and microwave oven drying was finally suggested for postharvest handling. It may provide a theoretical basis for further suitable exploitation and utilization of the leaf resources of the bamboo grasses.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Influence of Harvest Season and Drying Method on the Antioxidant Activity and Active Compounds of Two Bamboo Grass Leaves

Zhang

et al. 2013

Journal of Food Processing and Preservation

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“…Many recent studies have described the beneficial health effects of Sasa species leaves, which have been used as alternative medicines. S. albomarginata extract reportedly has anticancer properties (Shibata et al, 1979). Both lignin and polysaccharide preparation from Sasa species reportedly have antitumor properties (Suzuki et al, 1968;Yamafuji & Murakami, 1968).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Anti-Inflammatory Activities of Sasa quelpaertensis Leaf Extracts

Kim¹,

Hwang²,

Shin³

et al. 2012

Phytochemicals as Nutraceuticals - Global Approaches to Their Role in Nutrition and Health

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“…[29][30][31] Previously, the anticancer properties of Sasa albomarginata and Sasa senanensis extracts have been demonstrated. 32,33 Moreover, lignin and polysaccharide preparations from Sasa kurilensis have been shown to inhibit the growth of sarcoma-180 tumor cells implanted in mice. 34 Sasa quelpaertensis Nakai is a bamboo grass native to Korea that only grows on Mt Halla on Jeju Island in South Korea.…”

Section: Introductionmentioning

confidence: 99%

Combination of Sasa quelpaertensis Nakai Leaf Extract and Cisplatin Suppresses the Cancer Stemness and Invasion of Human Lung Cancer Cells

Kim

et al. 2014

Integr Cancer Ther

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Lung cancer is the leading cause of cancer death worldwide, and most chemotherapeutic drugs have limited success in treating this disease. Furthermore, some drugs show undesirable side effects due to the enrichment of cancer stem cells (CSCs) that are present, leading to resistance to conventional chemotherapy and tumor relapse. CSCs possess self-renewal characteristics, aggressive tumor initiating activity, and ability to facilitate tumor metastasis. Therefore, development of nontoxic agents that can potentiate chemotherapy and eliminate CSCs would be highly desirable. In the present study, we investigated whether Sasa quelpaertensis leaf extracts (SQE) and cisplatin (CIS), individually or in combination, would exert anti-CSC and antimetastatic effect in H1299 and A549 human lung cancer cells. Following these treatments, cell growth, phosphorylation of phosphoinositide-3 kinase, and activation of the mammalian target of rapamycin were inhibited. Decreased serial sphere formation, clonogenicity, and expression of major stem cell markers, such as CD44 and SOX-2, in CD44 + cancer stem cells were also observed. In addition, inhibition of cell migration and invasion in both cell lines as well as inhibition of matrix metalloproteinase-2 activity and expression were detected. Importantly, the anticancer stemness and antimetastasis effects in each of these assays were greater for the combined treatment with SQE and CIS than with each treatment individually. In conclusion, the data suggest that SQE alone, or in combination with CIS, represents a promising therapeutic strategy for eliminating cancer stemness and cell invasion potential of CSCs, thereby treating and preventing metastatic lung cancer cells.

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Pharmacological Studies on Bamboo Grass. IV. Toxicological and Pharmacological Effects of the Extract (FIII) obtained from Sasa albomarginata MAKINO et SHIBATA

Cited by 17 publications

References 0 publications

Influence of Harvest Season and Drying Method on the Antioxidant Activity and Active Compounds of Two Bamboo Grass Leaves

Influence of Harvest Season and Drying Method on the Antioxidant Activity and Active Compounds of Two Bamboo Grass Leaves

Antioxidant and Anti-Inflammatory Activities of Sasa quelpaertensis Leaf Extracts

Combination of Sasa quelpaertensis Nakai Leaf Extract and Cisplatin Suppresses the Cancer Stemness and Invasion of Human Lung Cancer Cells

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