PHARMACOLOGICAL STUDIES ON ROOT BARK OF MULBERRY TREE (Morus alba L.)

Abstract

Abstract-Pharmacological studies were done

Endothelium-independent relaxation and contraction of rat aorta induced by ethyl acetate extract from leaves of Morus alba (L.)

“…The constituents of the root bark were investigated by Nomura et al (1983) and Chu et al (2006), and many flavones and their derivatives were isolated as active principles. N-butanoland water-soluble fractions of the root are reported to suppress cough and reduce water retention, as well as having anticonvulsant and antihypertensive effects in mice, rats, guinea pigs and dogs (Yamatake et al, 1976). Water extracts of Morus alba leaf have long been included in a number of Sino-Japanese herbal prescriptions to reduce blood pressure (Jiangsu New Medicine College, 1977).…”

Phenolic Compounds of the Mulberry Tree and Related Plants

“…In addition, the root bark of the mulberry tree (Mori Cortex, Morus alba L. and other plants of the genus Morus) has been used as an antiphlogistic, diuretic, and expectorant in Chinese herbal medicine (3,4), and the crude drug is known as "Sohakuhi" in Japanese. In the pharmaceutical field, a few papers have been published reporting the hypotensive effect of this extract (5)(6)(7)(8)(9)(10)(11). The first of these reports was presented by FUKUTOME in 1938 who asserted that oral administration of the hot water extract of the mulberry tree showed a remarkable hypotensive effect in rabbits (5).…”

“…These rubraflavones are the first naturally occurring flavones with a ClO substituent (22). The heartwood of Artocarpus heterophyllus Lamarck (Jack tree, A. integrifolia), yielded artocarpin (5) (23,24), artocarpesin (11) (25), cycloartocarpesin (12) (26), oxydihydroartocarpesin (13) (26), cycloheterophyllin (14) (27), heterophyllin (15) (27), cycloartocarpin (16) (28), and isocycloheterophyllin (17) (29) (Fig. 2).…”

Antidiabetic Properties of 2,5-Dihydroxy-4,3′-Di(β-D-Glucopyranosyloxy)-trans-Stilbene from Mulberry (Morus bombycisKoidzumi) Root in Streptozotocin-Induced Diabetic Rats

“…has been used traditionally as an antihyperglycemic in China. 10,11 We reported the antioxidative and hepatoprotective effects of Morus bombycis and active components such as 2,5-dihydroxy-4,3Ј-di(␤-D-glucopyranosyloxy)-trans-stilbene (DGTS) isolated from this plant. 12,13 However, the possible antidiabetic effects inherent to the roots of M. bombycis had not, until now, been adequately investigated.…”