Endothelium-independent relaxation and contraction of rat aorta induced by ethyl acetate extract from leaves of Morus alba (L.)

Mao, Xia; Qian, Ling-Bo; Zhou, Xinmei; Gao, Qin; Bruce, Iain C.; Xia, Qiang

doi:10.1016/j.jep.2008.09.020

Cited by 33 publications

(19 citation statements)

References 25 publications

(31 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A substance causing inhibition of high K þ -induced contractions is considered as a blocker of calcium influx (Gilani et al, 2008;Borgi and Chouchane, 2009;Chiwororo et al, 2009;Dubraska et al, 2010). Therefore, our results (the inhibitory effect exhibited by PMAE against high K þ contractions) suggest that PMAE might inhibit the Ca 2 þ influx through voltage-operated Ca 2 þ channels (Xia et al, 2008;Borgi and Chouchane, 2009;Chiwororo and Ojewole, 2009;Dubraska et al, 2010) to produce non-selective spasmolytic effects. The spasmolytic effect may be attributed to the presence of some biochemical substances such as flavonoids which are reported to relax smooth muscles through inhibition of the entry of extracellular Ca 2 þ (Xia et al, 2008;Chen et al, 2009;Dubravka et al, 2010).…”

Section: Discussionmentioning

confidence: 61%

“…In smooth muscle cells, it is well known that Ca 2 þ is a critical factor in excitation-contraction coupling (Xia et al, 2008;Borrelli et al, 2009). A reduction in intracellular calcium leads to relaxation of intestinal smooth muscle.…”

Section: Discussionmentioning

confidence: 99%

“…Each concentration was added to the bath solution and its effects were recorded for 20 min. Time-response curve of each concentration of the extract was then constructed (Xia et al, 2008). Similarly, the effects of atropine (0.713 mg/mL) and promethazine (0.5 mg/mL), standard antispasmodic drugs were examined and served as positive controls.…”

Section: Assessment Of the Effects Of The Extract On Spontaneous Contmentioning

confidence: 99%

See 2 more Smart Citations

Effects of the aqueous extract of Pittosporum mannii Hook. f. (Pittosporaceae) stem barks on spontaneous and spasmogen-induced contractile activity of isolated rat duodenum

Joseph

Esther

Benoît

et al. 2015

Journal of Ethnopharmacology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Section: Assessment Of the Effects Of The Extract On Spontaneous Contmentioning

confidence: 99%

See 1 more Smart Citation

Effects of the aqueous extract of Pittosporum mannii Hook. f. (Pittosporaceae) stem barks on spontaneous and spasmogen-induced contractile activity of isolated rat duodenum

Joseph

Esther

Benoît

et al. 2015

Journal of Ethnopharmacology

View full text Add to dashboard Cite

“…According to Xia et al, (2008) ethyl acetate extract from leaves of Morus Alba showed vasoactive effect on studies in isolated ratthoracic ring. Mulberry juice showed anti-stress activity against mice, which inhibited the elevation of plasmalipid peroxide levels induced by stress (Sakagami et al, 2006).…”

Section: Vasoactive and Neuroprotective Actionmentioning

confidence: 99%

Biochemical Composition and Pharmacological Properties of Mulberry (Morus spp.) - A Review

Mahesh¹,

Vidhathri²,

Vidyashree³

et al. 2017

Int.J.Curr.Microbiol.App.Sci

View full text Add to dashboard Cite

Mulberry leaves contains (g kg-.07 mg/100 gm, respectively. Concentrations of total phenolic compounds like tannins, alkaloids and saponins were within safe range. Analyses of mineral composition indicated that potassium was the main mineral of fruit followed by sodium and phosphorus. Carbohydrate content is highly significant in apical leaf (f<0.05) and less significant in middle and bottom leaf (f>0.05). Antioxidant activities ranged from 22.85-76.88 μmol/100g quercetin equivalents. Anti HIV and chemo-protective activities have also been reported. The wide range of important pharmacological activities including antidiabetic, antimicrobial, antioxidant, anticancer, hypocholesterolemic, nephroprotective and various other effects like adaptogenic effect, effect on hyperlipidemia, inhibition of melanin biosynthesis used in psychiatric disorder also in gut and airways disorders. The plant is a very good source of ascorbic acid of which over 90% is present in a reduced form, and also contains carotene, vitamin b1, folic acid, folinic acid, isoquercetin, quercetin, tannins, flavonoids and saponins. Due to its chemical composition and pharmacological functions it is being utilized as a medicinal plant. Many active compounds isolated from the mulberry plants which used as medicines. Biochemical compounds such as Moranolin, Moran (glycopeptides), hydrophobic flavonoids (flavones and flavonone), 2-Arylbenzofuran and Ethanolic extract, Flavonoids, Polyphenols, Carotenoids, Vitamins A, C, E, Ethyl acetate, γ -aminobutyric acid, Flavanics are isolated from different parts of mulberry plants which play a vital role in hypoglycemic activity, anti-obesity action, lipid-lowering action, antioxidants action, anti-inflammatory actions, antiallergic action, vasoactive action, neuroprotective action, anticancer action. Mulberry plants are identified for their profitable health consequences and therefore attracted the attention of the pharmaceutical industry. The main objective of present reviews to provide the active principles of mulberry plants.

show abstract

“…Many synthetic drugs are used to treat hypertension, but they have various adverse effects. Recently, the use of natural herbs has steadily grown because of their low toxicity and well-established therapy strategy [4] . Many of the plants used in traditional medicine have been investigated for treating cardiovascular disease [5] .…”

Section: Introductionmentioning

confidence: 99%

Endothelium-independent vasorelaxant effect of 20(S)-protopanaxadiol on isolated rat thoracic aorta

et al. 2016

View full text Add to dashboard Cite

Aim: Ginsenosides are considered to be the major pharmacologically active ginseng constituents, whereas 20(S)-protopanaxadiol [20(S)-PPD] is the active metabolite of ginsenosides in gut. In this study we investigated the effect of 20(S)-PPD on isolated rat thoracic aortas as well as its vasorelaxant mechanisms. Methods: Aortic rings with or without endothelium were prepared from Wistar rats and suspended in organ-chambers. The changes in tension of the preparations were recorded through isometric transducers connected to a data acquisition system. The aortic rings were precontracted with phenylephrine (PE, 1 µmol/L) or high-K + (80 mmol/L).

show abstract

Endothelium-independent relaxation and contraction of rat aorta induced by ethyl acetate extract from leaves of Morus alba (L.)

Cited by 33 publications

References 25 publications

Effects of the aqueous extract of Pittosporum mannii Hook. f. (Pittosporaceae) stem barks on spontaneous and spasmogen-induced contractile activity of isolated rat duodenum

Effects of the aqueous extract of Pittosporum mannii Hook. f. (Pittosporaceae) stem barks on spontaneous and spasmogen-induced contractile activity of isolated rat duodenum

Biochemical Composition and Pharmacological Properties of Mulberry (Morus spp.) - A Review

Endothelium-independent vasorelaxant effect of 20(S)-protopanaxadiol on isolated rat thoracic aorta

Contact Info

Product

Resources

About