Back Cover: A multifunctional folate targeted ribotoxinpolymeric/lipid nanoformulation is used to image and specifically arrest the proliferation tendencies of human glioblastoma by additionally suppressing the anti‐apoptotic survivin and membrane interaction vinculin proteins. The formulation presented by D. S. Kumar and co‐workers http://doi.wiley.com/10.1002/mabi.201400248 could be used as a potent theranostic vector system for diverse cancer subtypes.
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disability-free survival outcome was defined as absence of dementia, persistent disability or death. Selection of potential predictors from amongst 25 biomedical, psychosocial and lifestyle variables including recognized geriatric risk factors, utilizing a machine-learning approach. Separate models were developed for men and women. The selected predictors were evaluated in a multivariable Cox proportional hazards model and validated internally by bootstrapping. We included 19,114 Australian and US participants aged ≥65 years (median 74 years, IQR 71.6–77.7). Common predictors of a worse prognosis in both sexes included higher age, lower Modified Mini-Mental State Examination score, lower gait speed, lower grip strength and abnormal (low or elevated) body mass index. Additional risk factors for men included current smoking, and abnormal eGFR. In women, diabetes and depression were additional predictors. The biased-corrected areas under the receiver operating characteristic curves for the final prognostic models at 5 years were 0.72 for men and 0.75 for women. Final models showed good calibration between the observed and predicted risks. We developed a prediction model in which age, cognitive function and gait speed were the strongest predictors of disability-free survival in healthy older people.Trial registrationClinicaltrials.gov (NCT01038583)
A silica nanoparticle‐based drug‐delivery system developed by D. S. Kumar and co‐workers for transporting multiple drugs and imaging agents is armed with tripletargeting ligands, which home in on cancer and angiogenic cells in a collegial fashion. This high‐precision, multi‐target concept described culminates in an effective therapeutic nanoformulation against breast cancer cells, completely disabling the migration and angiogenic sprouting abilities of activated endothelial cells, achieving both anti‐cancer and anti‐angiogenic potential in a singular lethal form. This nanoscheme could become the paragon for future cancer/angiogenesis treatment strategies.
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