Drug Delivery: Synergistic Targeting of Cancer and Associated Angiogenesis Using Triple‐Targeted Dual‐Drug Silica Nanoformulations for Theragnostics (Small 22/2012)

Veeranarayanan, Srivani; Poulose, Aby Cheruvathoor; Mohamed, M. Sheikh; Varghese, Saino Hanna; Nagaoka, Yutaka; Yoshida, Yasuhiko; Maekawa, Toru; Kumar, D. Sakthi

doi:10.1002/smll.201290123

Cited by 2 publications

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“…Such step‐by‐step drug release resulted in improved therapeutic index with reduced toxicity and would provide an “integrative” strategy for tumor therapy. Recently, a similar synergistic targeting nanoparticle, delivering antitumor and anti‐angiogenic agents and functionalized with triple targeting ligands specific towards tumor cells and angiogenesis simultaneously, was reported 152. Based on the pivotal role of TGF‐ β signaling pathway in regulating cancer progression through its effects on both the tumor microenvironment and the tumor cells, Kataoka and co‐workers showed that the application of TGF‐ β type I receptor (T β R‐I) inhibitor at a low dose decreased pericyte coverage of the endothelium specifically in the tumor neovasculature, without reducing endothelial area, and promoted accumulation of nanomaterials loaded with chemotherapeutic drugs in the tumor microenvironment 153, 154.…”

Section: Using Nanomaterials To Target and Regulate The Tumor Micrmentioning

confidence: 99%

ToF‐SIMS imaging and spectroscopic analyses of PEG‐conjugated AuNPs

Shon

Son

Park

et al. 2011

Surface & Interface Analysis

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Gold nanoparticles (AuNPs) and poly(ethylene glycol) (PEG) are known safe materials to be used in vivo, and so, are becoming increasingly important in biomedical applications. Here, the stability of PEG-conjugated AuNPs in an aqueous solution was monitored as a function of time using several techniques, namely dynamic light scattering (DLS)-size analysis, UV-visible absorption spectrometry and ToF-SIMS. Roughly 15-nm-sized AuNPs were synthesized and pegylated with mPEG (MW = 5 kDa). Four different samples were synthesized, depending on whether or not a dialysis procedure was performed right after synthesis of the AuNPs or pegylation of the AuNPs. The DLS results show that size of mPEG-conjugated AuNPs and standard deviation increased in cases where a dialysis procedure was performed after pegylation of the AuNPs, indicating aggregation of the AuNPs due to the detachment of mPEG ligands from the surface of the AuNPs. Also, results from UV-visible absorption spectra and ToF-SIMS images point to the likelihood that free mPEG ligands in solution help prevent aggregation by maintaining a dynamic equilibrium between the conjugated ligands on the surface of the AuNPs and the free ligands in the aqueous solution. Conversely, once free, mPEG ligands were eliminated from the solution by dialysis and conjugated mPEG ligands detached from the surface of AuNPs into the solution, suspension stability lowered and the AuNPs showed signs of aggregation. We believe that the ToF-SIMS imaging analysis with DLS and UV-visible absorption analyses would be useful to study the stability of PEG-conjugated AuNPs in different environmental conditions.

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Section: Using Nanomaterials To Target and Regulate The Tumor Micrmentioning

confidence: 99%

ToF‐SIMS imaging and spectroscopic analyses of PEG‐conjugated AuNPs

Shon

Son

Park

et al. 2011

Surface & Interface Analysis

View full text Add to dashboard Cite

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Using Functional Nanomaterials to Target and Regulate the Tumor Microenvironment: Diagnostic and Therapeutic Applications

et al. 2013

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Malignant tumors remain a major health burden throughout the world and effective therapeutic strategies are urgently needed. Cancer nanotechnology, as an integrated platform, has the potential to dramatically improve cancer diagnosis, imaging, and therapy, while reducing the toxicity associated with the current approaches. Tumor microenvironment is an ensemble performance of various stromal cells and extracellular matrix. The recent progress in understanding the critical roles and the underlying mechanisms of the tumor microenvironment on tumor progression has resulted in emerging diagnostic and therapeutic nanomaterials designed and engineered specifically targeting the microenvironment components. Meanwhile, the bio-physicochemical differences between tumor and normal tissues have recently been exploited to achieve specific tumor-targeting for cancer diagnosis and treatment. Here, the major players in the tumor microenvironment and their biochemical properties, which can be utilized for the design of multifunctional nanomaterials with the potential to target and regulate this niche, are summarized. The recent progress in engineering intelligent and versatile nanomaterials for targeting and regulating the tumor microenvironment is emphasized. Although further investigations are required to develop robust methods for more specific tumor-targeting and well-controlled nanomaterials, the applications of tumor microenvironment regulation-based nanotechnology for safer and more effective anticancer nanomedicines have been proven successful and will eventually revolutionize the current landscape of cancer therapy.

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Drug Delivery: Synergistic Targeting of Cancer and Associated Angiogenesis Using Triple‐Targeted Dual‐Drug Silica Nanoformulations for Theragnostics (Small 22/2012)

Cited by 2 publications

References 0 publications

ToF‐SIMS imaging and spectroscopic analyses of PEG‐conjugated AuNPs

ToF‐SIMS imaging and spectroscopic analyses of PEG‐conjugated AuNPs

Using Functional Nanomaterials to Target and Regulate the Tumor Microenvironment: Diagnostic and Therapeutic Applications

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