Various studies have shown that the prevalence of CAD among diabetic patients is higher than non-diabetic patients. 3 It is also seen in literature that the prevalence of CAD among the urban is higher compared to rural patients. 2 CAD in diabetic patient is mainly owing to dyslipidemia (raised triglycerides, raised cholesterol and low HDL). Both persistent hyperglycaemia and dyslipidemia, especially raised LDL and low HDL eventually causes ABSTRACT Background: The patients with type 2 diabetes have an increased prevalence of lipid abnormalities (Dyslipidemia). Early diagnosis of diabetic patients with silent CAD and dyslipidemia can reduce the morbidity and mortality for cardiovascular death. The objective of the present study is to assess the prevalence of silent coronary disease among south Indian type-2 diabetic patients without cardiovascular symptoms and association between lipid profile and silent coronary disease among them. Methods: 100 Type 2 diabetes mellitus patients (65 males and 35 females) of age 40-80 years attending the OPD of Sri Siddhartha Medical College, Tumakuru, Karnataka, India were enrolled in this study. The Serum samples were analysed for fasting blood glucose (FBS), post prandial blood glucose (PPBS), HbA1c, and lipid profile. The patients were classified into CAD and Non CAD groups based on ECG changes and stress test. Results were analysed SPSS 16.0 software. Results: The study revealed that 46% of our study population had silent CAD. The prevalence of dyslipidemia was found higher in males than females in both study groups. CAD group patients had significantly higher levels of serum total cholesterol, triglycerides, LDL-cholesterol and low HDL-cholesterol compared to Non CAD group. Conclusions: Dyslipidemia is indicating the strong association with silent CAD in type 2 diabetes mellitus. It is also advisable to have a screening ECG for silent CAD at the time of diagnosis or during the follow-up period in type 2 diabetes.
Introduction: Snake bite is an important health problem in the tropical world including India. Snake venom contains many toxins which interact with clotting mechanism and brinolytic system causing coagulopathy. Awareness and educating the farmers and laborers who walks in barefoot in elds while walking in night is needed to prevent the snake bites. Hence this study was conducted to evaluate the clinical and laboratory parameters of coagulopathy.Aim of the study: To study the coagulation prole and hematological parameters for detection of snake bite and aid in early treatment. Materials And Methods: Total of 50 Patients with history of snake bite were considered in this study from January 2021 – June 2022. Detailed history, physical examination and following investigations were performed. Complete haemogram,whole blood clotting time, prothrombin time and a partial thromboplastin time were done. Results: Out of 50 patients,30(58%) patients showed anemia with Hemoglobin <10 gm%, Leukocytosis (Total count >11,000) in 12 (18%) patients and thrombocytopenia (platelet count <1.5 lakh) in 26 (52%) patients.Also 70% of the patients had prolonged whole blood clotting time that is more than 20 minutes.PT-INR was prolonged (>1.2 seconds) in 45 (95%) patients and APTT was prolonged (>28 seconds) in 48 (96%) patients respectively. Conclusion: Snake bite is a major public health problem Combined clinical and laboratory parameters evaluation needed to identify the coagulopathy very early to reduce the hospital stay and mortality.
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