Study of Haematologicaland Coagulation Profile in Snake Bite and Its Outcome in Tertiary Care Hospital.

Abstract

Introduction: Snake bite is an important health problem in the tropical world including India. Snake venom contains many toxins which interact with clotting mechanism and brinolytic system causing coagulopathy. Awareness and educating the farmers and laborers who walks in barefoot in elds while walking in night is needed to prevent the snake bites. Hence this study was conducted to evaluate the clinical and laboratory parameters of coagulopathy.Aim of the study: To study the coagulation prole and hematological parameters for detection of snake bite and aid in early treatment. Materials And Methods: Total of 50 Patients with history of snake bite were considered in this study from January 2021 – June 2022. Detailed history, physical examination and following investigations were performed. Complete haemogram,whole blood clotting time, prothrombin time and a partial thromboplastin time were done. Results: Out of 50 patients,30(58%) patients showed anemia with Hemoglobin <10 gm%, Leukocytosis (Total count >11,000) in 12 (18%) patients and thrombocytopenia (platelet count <1.5 lakh) in 26 (52%) patients.Also 70% of the patients had prolonged whole blood clotting time that is more than 20 minutes.PT-INR was prolonged (>1.2 seconds) in 45 (95%) patients and APTT was prolonged (>28 seconds) in 48 (96%) patients respectively. Conclusion: Snake bite is a major public health problem Combined clinical and laboratory parameters evaluation needed to identify the coagulopathy very early to reduce the hospital stay and mortality.