Introduction: Blood transfusion is an essential element in modern health care. Transfusion of blood and blood components has become an integral part of patient management in modern medicine. Human blood till date has no substitute. Demand of blood and its components always outpace its supply. This emphasizes the need for proper utilization of blood and its components with preferably "NO" or minimal wastage. Materials and methods: A Retrospective study of analysis was carried out at Sri Siddhartha Medical College Hospital Blood bank from 1 st January 2017 to December 31 st 2017. Results: Out of 1806 whole blood bags, 371 (5.21%) were discarded. 137 (36.9%) units were discarded because of transfusion transmitted infections (TTIs). Out of 11809 components prepared, 1027 (8.6%) were discarded. Most common component discarded was platelet (40.7%) and reason for discard was date of expiry due to non-utilization. Conclusion: Blood being irreplaceable source, discard rate can be reduced by proper counseling of blood donors and adhering to strict donor deferral criteria. Discard rate of platelet concentrate can be minimized by preparing platelet concentrate on request and also by using modern technique like Apheresis.

Introduction: Snake bite is an important health problem in the tropical world including India. Snake venom contains many toxins which interact with clotting mechanism and brinolytic system causing coagulopathy. Awareness and educating the farmers and laborers who walks in barefoot in elds while walking in night is needed to prevent the snake bites. Hence this study was conducted to evaluate the clinical and laboratory parameters of coagulopathy.Aim of the study: To study the coagulation prole and hematological parameters for detection of snake bite and aid in early treatment. Materials And Methods: Total of 50 Patients with history of snake bite were considered in this study from January 2021 – June 2022. Detailed history, physical examination and following investigations were performed. Complete haemogram,whole blood clotting time, prothrombin time and a partial thromboplastin time were done. Results: Out of 50 patients,30(58%) patients showed anemia with Hemoglobin <10 gm%, Leukocytosis (Total count >11,000) in 12 (18%) patients and thrombocytopenia (platelet count <1.5 lakh) in 26 (52%) patients.Also 70% of the patients had prolonged whole blood clotting time that is more than 20 minutes.PT-INR was prolonged (>1.2 seconds) in 45 (95%) patients and APTT was prolonged (>28 seconds) in 48 (96%) patients respectively. Conclusion: Snake bite is a major public health problem Combined clinical and laboratory parameters evaluation needed to identify the coagulopathy very early to reduce the hospital stay and mortality.

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o evaluate the changes in PIH (Pregnancy Induced Hypertension) by using haematologicaland coagulation parameters like platelet count, MPV, PDW, PT and APTT. Materials and methods: Atotal of 150 cases comprising 75 control groups and 75 cases group (pregnancy-inducedhypertension) were enrolled in the study. Hematological parameters like platelet count, MPV, PDWand coagulation parameters like PT and APTT were studied in these patients. Data entry was done inan excel spreadsheet and by using SPSS (version -20). Results: The hematological parameter -Platelet count was markedly reduced in patients with preeclampsia compared to normal pregnantpatients. MPV, PDW, PT and APTT were increased which is statistically significant. Conclusion: Theabnormalities about hematological and coagulation parameters in preeclampsia are the prognosticmarkers used as an additional diagnostic criterion for preeclampsia in rural hospitals.