be in considerable degree interpreted on the assumption that the initial process is the attachment of one water molecule to each polar aminoacid side chain. The data also indicate that peptide carbonyl and imido groups usually do not bind water, because of their mutual interaction by hydrogen-bond formation, but that water is bound by carbonyl groups which are not coupled by hydrogen bonds with imido groups. In salmin, in which most of the amino-acid residues are polar, these polar residues codperate to attach one water molecule jointly to two polar groups in the initial process of hydration.
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