h e synthesis of several steroidai liP-adamanloate esters is described. "lie ad:iiiurti!oic ester of 19-iiurlcw tosterotie produce& a profound arid unique effect on anabolic potency as compared Kith other esters. The long diiratiori of high rnyotropic activity with diminished androgeriic.it,y-ma!-be an indication that, the ester is act'irrg in toto as opposed to prior hydrolysis to the parent compound. The action of this anabolic ester over a period of several weeks after a single injection is confirmed by the radioactive :tniirioisobut,yric acid (AIB) C14 uptake data.

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The observation1 that 2-hydroxy-3-phenyl-1,4-naphthoquinone2 (IV, Ri = R.2 = Rs = H) has an activity approximately one-fourth that of quinine against P. lophurae in ducks, prompted further investigation in this series.It was decided to diversify the method used by Volhard2 in the preparation of the parent compound, by starting with various substituted phenylacetic esters (I). In this way nine new