The observation1 that 2-hydroxy-3-phenyl-1,4-naphthoquinone2 (IV, Ri = R.2 = Rs = H) has an activity approximately one-fourth that of quinine against P. lophurae in ducks, prompted further investigation in this series.It was decided to diversify the method used by Volhard2 in the preparation of the parent compound, by starting with various substituted phenylacetic esters (I). In this way nine new
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