A survey was carried out of a population of workers exposed to tetrachlorophthalic anhydride, an acid anhydride epoxy resin curing agent known to cause asthma. Using a radioallergosorbent test with a tetrachlorophthalic anhydride human serum albumin conjugate, specific IgE antibody was detected in serum from 24 out of 300 factory floor workers exposed to tetrachlorophthalic anhydride. Of these 24, 20 (83-3%) were current smokers compared with 133 (48 2%) of 276 without antibody (p <0 01), and there was a weaker association with atopy, defined by skin tests with common allergens. Smoking and atopy interacted, the prevalence of antibody being 16 1% in atopic smokers, 11-7% in non-atopic smokers, 8-3% in atopic non-smokers, and nil in non-atopic non-smokers (p <0 025). Smoking may predispose to, and interact with atopy in, the production of specific IgE antibody to this hapten protein conjugate.

The Control of Substances Hazardous to Health Regulations 1994 (COSHH), provide the main British legislation to protect against health risks arising from hazardous substances used at work. Under the regulations, employers have a duty to carry out a suitable and sufficient risk assessment and take steps to ensure exposure is adequately controlled. The paper by Topping et al. (1998) concluded that small firms need more basic, readily available advice on how to effectively control hazardous substances. To meet this need the Health and Safety Executive (HSE) and the Advisory Committee on Toxic Substances (ACTS) have developed a new scheme for the UK. It involves a simple system of generic risk assessments to identify appropriate control strategies and a series of control guidance sheets providing good-practice examples of those strategies for common operations. The approach builds on earlier industry risk banding schemes and HSE's general approach to risk assessment and risk management. To help ensure the advice reaches small firms, HSE is seeking to involve key intermediaries in its dissemination. This paper describes the rationale for the new UK scheme, how it sits in the legal framework, and proposals for its dissemination. The papers by Brooke (1998) and Maidment (1998) set out in detail the technical basis for the scheme.

The role of pyroglyphid mites in house dust allergy is well established and the major allergens from the common house dust mites (Dermatophagoides species) have been characterized. There is, however, relatively little progress in the understanding of the human IgE response to non-pyroglyphid storage mites, allergenic crossreactivity with other mite species and extent of environmental exposure. We studied 196 individuals from an urban environment who were not occupationally exposed to storage mites and found a 24% prevalence of specific IgE antibody to Dermatophagoides pteronyssinus and a 14% prevalence of RAST positivity to at least one of three storage mites, Acarus siro, Lepidoglyphus destructor and Tyrophagus longior. All individuals with a positive RAST to storage mites had specific IgE to D. pteronyssinus. RAST inhibition studies with the eight sera with greater than 2% RAST binding to both families of mites showed considerable crossreactivity between D. pteronyssinus and the storage mites A. siro and T. longior and limited crossreactivity between D. pteronyssinus and L. destructor. This suggests that at least some of the response to storage mites observed by direct RAST is a consequence of crossreactivity with the more abundant D. pteronyssinus.

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A questionnaire survey of over 400 workers handling reactive dyes showed that over 15% had work related respiratory or nasal symptoms. Forty nine employees with symptoms were referred to chest clinics for detailed assessment attributed to reactive dyes. He had been advised by his trade union to consult his local Employment Medical Adviser. Two and a half years previously a colleague from the same dyehouse had been investigated for occupational asthma. Inhalation testing with a Levafix orange reactive dye provoked an asthmatic response; the dye was subsequently withdrawn from his place of work. This man's death at work with asthma gave urgency to this study.The first phase of the study was to identify, by means of a questionnaire administered by a physician, those dyehouse operatives with work related upper and lower respiratory tract symptoms. Symptomatic employees identified by the questionnaire were referred to one of two chest physicians who investigated the nature of their symptoms, their severity, relation with work, and the possible causative agents. The study included an estimate of the prevalence of specific IgE to dye-human serum albumin conjugates (dye-HSA) as a measure of immunological response in employees exposed to reactive dyes, and to relate this to symptoms, atopy, and smoking.In the present paper we report the clinical and immunological findings on the employees referred to 534 on 11 May 2018 by guest. Protected by copyright.