Clinical and immunological investigations of respiratory disease in workers using reactive dyes.

Docker, A; Wattie, J M; Topping, M. D.; Luczynska, Christina; Taylor, A J Newman; Pickering, C. A. C.; Thomas, Peter D. G.; Gompertz, D.

doi:10.1136/oem.44.8.534

Cited by 36 publications

(48 citation statements)

References 3 publications

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“…This points to a rela tively minor sensitivity of the scratch tests to PA. The prick tests with HSA conjugates of acid anhydrides show posi tive results more frequently [4,8,9], but are connected with a considerable expenditure [4,12], Acetonic solutions of the hardly water-soluble acid anhydrides, however, are cheap, easy to produce and give results which are compa rable to those of RAST. Because the sensitizing capacity of the acetonic solutions of the anhydrides is difficult to esti mate, particularly when applied repeatedly, it seems to be more safe to perform a RAST or the skin prick test with HSA conjugates, if they are available.…”

Section: Discussionmentioning

confidence: 99%

Skin Prick Tests with Solutions of Acid Anhydrides in Acetone

Drexler¹,

Schaller²,

Weber³

et al. 1993

Int Arch Allergy Immunol

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Various low molecular acid anhydrides can act as haptens and induce type I allergies. Immunoglobulin E can be detected by radioallergosorbent test (RAST) with the protein conjugates of the respective anhydrides, which are commercially available for some substances. Being almost nonsoluble in water, these species cannot be applied in a skin prick test as a water solution. We will introduce a practicable skin prick test using acetonic solutions of the haptens. 136 persons were tested with acetone for negative control and histamine for positive control. Tests were carried out with 1 and 5% acetonic solutions of phthalic anhydride (PA). The RASTs with conjugates of the PA were performed with Ill subjects who had been exposed to acid anhydrides and with 5 people who possibly had been exposed. In 14 cases, when immediate-type allergy was suspected clinically, a test was performed in addition to the respective anhydride used at the workplace. In order to avoid unspecific histamine liberation, we tested 20 volunteer control persons who had not been occupationally exposed to acid anhydrides. In the prick test performed with acetonic PA solutions, 10 of the occupationally exposed subjects, who had also had a positive result in the RAST with protein conjugates of the PA, showed positive skin reactions, and in 2 further cases, in which the skin reaction was positive, the results of the RAST were just below the limit of a positive evaluation. The skin reaction was positive in 4 cases, in spite of a negative RAST result, while the prick test was reported to be negative in 3 cases although the RAST results were considered to be positive. 97 subjects occupationally exposed to acid anhydrides showed no positive RAST for specific IgE against PA conjugates as well as no positive skin prick test. None of the subjects not occupationally exposed had a positive reaction against any solution, and none of the 136 tested persons developed a positive skin reaction to the solvent acetone. Acetone seems to be practicable for the skin prick test. From a toxicological point of view, it is a harmless solvent for acid anhydrides which are almost nonsoluble in water.

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Section: Discussionmentioning

confidence: 99%

Skin Prick Tests with Solutions of Acid Anhydrides in Acetone

Drexler¹,

Schaller²,

Weber³

et al. 1993

Int Arch Allergy Immunol

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“…1978;Estlander, 19881 [Alanko et al, 1978: Docker et al, 1987Estlander. 19881 [Docker et al, 19871 [Docker et al.…”

Section: Case Reportmentioning

confidence: 98%

“…19871 [Ringenbach. !9SS] [ Docker et al, 1987;Estlander. 19881 [Docker et al, 19871 70800 anthraquinone [Docker et al.…”

Section: Case Reportmentioning

confidence: 99%

A new case of occupational asthma from reactive dyes with severe anaphylactic response to the specific challenge

Romano

Sulotto

Pavan

et al. 1992

American J Industrial Med

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A case of occupational asthma in a wool and cotton dyer handling reactive dyes is described. The patient was skin positive, but asymptomatic to house dust mites. A bromoacrilamidic dye (Lanasol Yellow 4G) has been identified through chamber inhalation challenge as being responsible for the sensitization. A very short (4-minute) exposure produced a severe immediate obstructive ventilatory defect followed by arterial hypotension and urticaria. Bronchial hyperresponsiveness as tested through metacholine challenge was absent both in basal conditions and after the dye challenge. Both prick and patch test for the dye were positive in the absence of any sign of contact dermatitis.

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“…The clinical features indicate that the symptoms may, at least in some cases, be caused by a true type I hypersensitivity reaction. Associations between allergy-like respiratory symptoms and specific immunoglobulin (Ig) E antibodies have been demonstrated for isocyanates (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19), reactive textile dyes (20)(21)(22)(23)(24), acid anhydrides (25)(26)(27)(28)(29), platinum group metal salts (30,31), and the disinfectant chloramine-T (p-toluenesulfonamide, n-chloro, sodium salt, trihydrate; CAS 127-65-1) (32,33). Furthermore, traces of the sterilizing gas ethylene oxide in hemodialysis filters have been shown to sensitize patients undergoing treatment (34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)…”

mentioning

confidence: 99%