Objective: This study aimed to obtain the physicochemical properties of hydroxypropyl cellulose (HPC) powder from α-cellulose Betung bamboo and its characteristics in tablet formulation.Methods: HPC was prepared by hydroxypropylation of α-cellulose using 25% (w/v) sodium hydroxide and 10 ml propylene oxide (based on 1 g αcellulose) at 70 °C for 3 h. HPC of Betung bamboo (HPC BB) was characterized using fourier transform infrared (FTIR) spectrometry, particle size analyzer (PSA), x-ray diffraction (XRD), scanning electron microscope (SEM) and compared to HPC grade SL (HPC SL) as the reference. Then, HPC BB was used as a binder in tablet formulation by direct compression method and the resulted tablets were evaluated. The tablets evaluation including weight and size uniformity, hardness, friability and disintegration time. Results:The results showed HPC BB powder was yellowish white, odorless and tasteless, pH 7.49, residue on ignition 0.68%, hydroxypropoxy groups content 54.75%, average particle size 37.39 μm, loss on drying 1.09%, and moisture content 3.34%. Flow properties of powder fulfilled the requirements based on literature. Infrared spectrum and diffraction pattern of HPC BB were relatively similar to HPC SL. The tablets have average weight 403.495 mg, diameter 12.16 mm, thickness 3.11 mm, hardness 4.11 KPa, friability 2.04% and disintegration time 24.88 s. Conclusion:Based on the comparison of powder characteristics and tablets evaluation, HPC BB has a great potential in tablet formulation which showed similar characteristics to reference. I In nt te er rn na at ti io on na al l J Jo ou ur rn na al l o of f A Ap pp pl li ie ed d P Ph ha ar rm ma ac ce eu ut ti ic cs s

Ice slurry has so many advantages as phase-change slurries due to the high latent heat of its particles. Ice slurry is one of a competitive alternative to conventional secondary refrigeration systems that have been successfully employed in many applications. In this research, ice slurry flow with monoethylene glycol (MEG) at high ice fractions was investigated. The experiment was carried out by measuring shear stress and flow rate as variable to calculate power law index. The experiment was performed in 14 mm, 21 mm, and 24 mm circular tubes, respectively. The Initial concentration of 5 wt%, 7 wt%, and 10 wt% of MEG was investigated. Ice fraction was maintained above 30% in a storage tank. Experimental results of the Darcy friction factor were compared to Poiseuille and Blasius model. The ice slurry flows exhibited a shear-thickening flow (n>1) for all initial concentration in the range 1.07 - 1.58. The Greater initial concentration of MEG tends to give smaller friction compared with another ice slurry flow with smaller initial concentration.

A new device for air lubrication called the Winged Air Induction Pipe (WAIP) is studied in the present work. The device, which consists of an angled hydrofoil, uses the low-pressure region produced above the hydrofoil as a ship moves forward. The low pressure drives the atmospheric air into the water at certain velocities when the pressure is negative compared to atmospheric pressure. A computational fluid dynamics approach is presented in the study of the effect of the hydrofoil clearance of the Winged Air Induction Pipe on the drag reduction experienced by the plate to which the WAIP is attached. The well-known 'volume of fluid' model and k- SST (shear stress transport) turbulence closure model were used in the 2D numerical simulation in ANSYS Fluent. The numerical simulation was conducted with different hydrofoil clearance and angle of attack configurations, and the effects of these parameters on total drag force and drag reduction are reported. The reduction of drag force is found to increase by about 10% compared to the bare plate configuration.

Objective: This study aim to obtain the optimum condition of preparation of hydroxypropyl methylcellulose (HPMC) produced from α-cellulose betung bamboo, physicochemical properties of HPMC powder and its characteristics in a gel formulation. Methods: HPMC of betung bamboo (HPMC BB) were optimized by central composite design (CCD) using three variables (sodium hydroxide concentration, dimethyl sulfate concentration, and temperature) and five levels (0,±1, and±α). The suggested optimum condition was subjected to further characterization. HPMC BB was characterized using Fourier transform infrared (FTIR) spectrometry, particle size analyzer (PSA), x-ray diffraction (XRD), scanning electron microscope (SEM) and compared to HPMC 60SH as the reference. Then, HPMC BB was used as a gelling agent in a gel formulation and the gel was evaluated, including appearance and homogeneity, pH, viscosity, and spreadability. Results: Optimum condition of preparation of HPMC BB was using sodium hydroxide 27.68% (w/v) and 1.26 ml dimethyl sulfate (based on 1 g α-cellulose) at 58.11 °C which resulted in molar substitution 0.21 and degree of substitution 2.09. The results showed that HPMC BB was a fine powder with yellowish-white color, odorless and tasteless, pH 7.02, residue on ignition 1.39%, methoxy groups content 28.56%, hydroxypropoxy groups content 7.09%, mean particle size 98.595 μm, loss on drying 3.62%, and moisture content 7.47%. Flow properties of HPMC BB classified in the fair category. The infrared spectrum and diffraction patterns were relatively similar to HPMC 60SH. The gel has a good homogeneity and spreadability and viscosity 142.5 mPa⋅s. pH 6.37. Conclusion: Based on the comparison to reference, HPMC BB showed relatively similar physicochemical and powder properties. However, HPMC BB is not recommended as a gelling agent in gel formulation because it has a low viscosity.

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