CHARACTERIZATION OF HYDROXYPROPYL CELLULOSE PRODUCED FROM Α-Cellulose BETUNG BAMBOO (DENDROCALAMUS ASPER) AND IT’S APPLICATION IN TABLET FORMULATION

Abstract

Objective: This study aimed to obtain the physicochemical properties of hydroxypropyl cellulose (HPC) powder from α-cellulose Betung bamboo and its characteristics in tablet formulation.Methods: HPC was prepared by hydroxypropylation of α-cellulose using 25% (w/v) sodium hydroxide and 10 ml propylene oxide (based on 1 g αcellulose) at 70 °C for 3 h. HPC of Betung bamboo (HPC BB) was characterized using fourier transform infrared (FTIR) spectrometry, particle size analyzer (PSA), x-ray diffraction (XRD), scanning electron microscope (SEM) and compared to HPC grade SL (HPC SL) as the reference. Then, HPC BB was used as a binder in tablet formulation by direct compression method and the resulted tablets were evaluated. The tablets evaluation including weight and size uniformity, hardness, friability and disintegration time. Results:The results showed HPC BB powder was yellowish white, odorless and tasteless, pH 7.49, residue on ignition 0.68%, hydroxypropoxy groups content 54.75%, average particle size 37.39 μm, loss on drying 1.09%, and moisture content 3.34%. Flow properties of powder fulfilled the requirements based on literature. Infrared spectrum and diffraction pattern of HPC BB were relatively similar to HPC SL. The tablets have average weight 403.495 mg, diameter 12.16 mm, thickness 3.11 mm, hardness 4.11 KPa, friability 2.04% and disintegration time 24.88 s. Conclusion:Based on the comparison of powder characteristics and tablets evaluation, HPC BB has a great potential in tablet formulation which showed similar characteristics to reference. I In nt te er rn na at ti io on na al l J Jo ou ur rn na al l o of f A Ap pp pl li ie ed d P Ph ha ar rm ma ac ce eu ut ti ic cs s

PREPARATION AND CHARACTERIZATION OF HYDROXYPROPYL METHYLCELLULOSE PRODUCED FROM Α-Cellulose BETUNG BAMBOO (DENDROCALAMUS ASPER) AND IT’S EVALUATION ON GEL FORMULATION

“…The fine bamboo powder was washed repeatedly with water, then dried at 60 °C for 24 h in an oven. About 300 g of fine bamboo powder was macerated with 3 l of n-hexane: ethanol (2:1) for 24 h and stirred every 8 h. The pulp was filtered and dried at room temperature [11].…”

“…The precipitate obtained is HPMC. It was washed 3 times with ethanol 96%, then dried using an oven at 50 °C for 6 h. HPMC powder was ground to a fine powder and stored in a desiccator [7,9,11].…”

“…The propylene glycol then dehydrated into propionaldehyde and the enolic form of allyl alcohol. Furthermore, these products were reacted with ninhydrin to form purple color, the absorbance was measured using UV-VIS spectrophotometer at a wavelength of 400-415 nm [11].…”

“…Another study of the preparation of methylcellulose from sugar cane bagasse cellulose showed that the use of sodium hydroxide 50% (w/v) and dimethyl sulfate 3 ml (for each 1 g of α-cellulose) at 50 °C for 3 h resulted in degree of substitution 1.2 [10]. The study of hydroxypropylation on α-cellulose betung bamboo showed that using sodium hydroxide 25% (w/v) and propylene oxide 10 ml (for each 1 g of α-cellulose) at 70 °C for 3 h resulted in molar substitution 3.32 [11]. Another study showed that hydroxypropylation on olive tree branch cellulose using sodium hydroxide 10% (w/v) and propylene oxide 115 g (for each 100 g of α-cellulose) at 60 °C for 2 h resulted in molar substitution 0.39 [8].…”

Growth response of Dendrocalamus asper on elevational variation and intra-clump spacing management

“…However, there is inadequate research intervention regarding the effect of environmental variations on D. asper growth and development. Previous studies showed that the study of bamboo was dominated by postharvest research during 1994-2019, i.e., tensile testing, strength properties, bending strength, physical and mechanical properties, several chemical compounds, post-harvest products (Nurhazwani et al 2016;Srivaro and Jakranod 2016;Kadivar et al 2019;Suryadi et al 2019;Widodo et al 2019). The growth of bamboo was affected by environmental factors i.e., altitude and temperature (Sonboon 2001) and clump density (Mera and Xu 2014).…”