In this paper, we present a novel control scheme for feedback optimization. That is, we propose a discretetime controller that can steer a physical plant to the solution of a constrained optimization problem without numerically solving the problem. Our controller can be interpreted as a discretization of a continuous-time projected gradient flow. Compared to other schemes used for feedback optimization, such as saddle-point schemes or inexact penalty methods, our control approach combines several desirable properties: it asymptotically enforces constraints on the plant steadystate outputs, and temporary constraint violations can be easily quantified. Our scheme requires only reduced model information in the form of steady-state input-output sensitivities of the plant. Further, global convergence is guaranteed even for non-convex problems. Finally, our controller is straightforward to tune, since the step-size is the only tuning parameter.
The insulin sensitivity (IS) of the human body changes with a circadian rhythm. This adds to the timevarying feature of the glucose metabolism process and places challenges on the blood glucose (BG) control of patients with Type 1 Diabetes Mellitus. This paper presents a Model Predictive Controller that takes the periodic IS into account, in order to enhance BG control. The future effect of the IS is predicted using a machine learning technique, namely, a customized Gaussian Process (GP), based on historical training data. The training data for the GP is continuously updated during closed-loop control, which enables the control scheme to learn and adapt to intra-individual and inter-individual changes of the circadian IS rhythm. The necessary state information is provided by an Unscented Kalman Filter. The closed-loop performance of the proposed control scheme is evaluated for different scenarios (including fasting, announced meals and skipped meals) through in silico studies on simulation models of Göttingen Minipigs.
The human insulin-glucose metabolism is a timevarying process, which is partly caused by the changing insulin sensitivity of the body. This insulin sensitivity follows a circadian rhythm and its effects should be anticipated by any automated insulin delivery system. This paper presents an extension of our previous work on automated insulin delivery by developing a controller suitable for humans with Type 1 Diabetes Mellitus. Furthermore, we enhance the controller with a new kernel function for the Gaussian Process and deal with noisy measurements, as well as, the noisy training data for the Gaussian Process, arising therefrom. This enables us to move the proposed control algorithm, a combination of Model Predictive Controller and a Gaussian Process, closer towards clinical application. Simulation results on the University of Virginia/Padova FDA-accepted metabolic simulator are presented for a meal schedule with random carbohydrate sizes and random times of carbohydrate uptake to show the performance of the proposed control scheme.
In this paper we propose an approach based on an Online Feedback Optimization (OFO) controller with grid input-output sensitivity estimation for real-time grid operation, e.g., at subsecond time scales. The OFO controller uses grid measurements as feedback to update the value of the controllable elements in the grid, and track the solution of a time-varying AC Optimal Power Flow (AC-OPF). Instead of relying on a full grid model, e.g., grid admittance matrix, OFO only requires the steady-state sensitivity relating a change in the controllable inputs, e.g., power injections set-points, to a change in the measured outputs, e.g., voltage magnitudes. Since an inaccurate sensitivity may lead to a model-mismatch and jeopardize the performance, we propose a recursive least-squares estimation that enables OFO to learn the sensitivity from measurements during real-time operation, turning OFO into a model-free approach. We analytically certify the convergence of the proposed OFO with sensitivity estimation, and validate its performance on a simulation using the IEEE 123-bus test feeder, and comparing it against a state-of-the-art OFO with constant sensitivity.
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