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Knee osteoarthritis (KOA) is one of the most common degenerative diseases, and its core feature is the degeneration and damage of articular cartilage. The cartilage degeneration of KOA is due to the destruction of dynamic balance caused by the activation of chondrocytes by various factors, with oxidative stress playing an important role in the pathogenesis of KOA. The overproduction of reactive oxygen species (ROS) is a result of oxidative stress, which is caused by a redox process that goes awry in the inherent antioxidant defence system of the human body. Superoxide dismutase (SOD) inside and outside chondrocytes plays a key role in regulating ROS in cartilage. Additionally, synovitis is a key factor in the development of KOA. In an inflammatory environment, hypoxia in synovial cells leads to mitochondrial damage, which leads to an increase in ROS levels, which further aggravates synovitis. In addition, oxidative stress significantly accelerates the telomere shortening and ageing of chondrocytes, while ageing promotes the development of KOA, damages the regulation of redox of mitochondria in cartilage, and stimulates ROS production to further aggravate KOA. At present, there are many drugs to regulate the level of ROS, but these drugs still need to be developed and verified in animal models of KOA. We discuss mainly how oxidative stress plays a part in the development of KOA. Although the current research has achieved some results, more research is needed.

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PurposeThe purpose of this study is to investigate whether Chinese college students' social cyberloafing out of class has a curvilinear effect on academic performance and whether students' levels of psychological detachment and relaxation mediate the effect.Design/methodology/approachA field survey was used to collect 502 self-reported responses from student Internet users at a large university located in central China.FindingsThe results show an inverted U-shaped relationship between social cyberloafing out of class and academic performance. Two types of effort recovery experience gained from social cyberloafing, psychological detachment and relaxation, mediate that effect. Students' social cyberloafing out of class is positively associated with psychological detachment and relaxation, which in turn, have opposite effects on academic performance.Practical implicationsThis study offers novel insights into the effects of social cyberloafing on college students' academic achievement. The findings illustrate how social cyberloafing can serve as a recovery experience and improve academic performance, but it can hinder performance if the cyberloafing is excessive.Originality/valueThis study extends the cyberloafing literature by focusing on Chinese college students' cyberloafing out of class. The study finds that a moderate amount of social cyberloafing out of class can result in psychological detachment, relaxation and improved performance when returning to academic work. However, both too much or too little social cyberloafing can result in difficulty returning to academic work and reduced academic performance. The findings are novel to the cyberloafing literature.

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