Because pregnant women must frequent health institutions to monitor their pregnancy, they are more prone to catching COVID 19. As a result, adherence to pregnant women’s behavior in preventing COVID 19 is critical. The elements that influence pregnant women’s behavior in terms of COVID 19 prevention are examined in this study. This research is a cross-sectional descriptive analytic non-experimental study. The incidental sampling approach was used to collect samples (n=102). The Chi square test and logistic regression were used to evaluate the data. The findings revealed that COVID 19 preventative behavior was influenced by knowledge, attitudes, fear of COVID 19, and belief in COVID 19 information. Following the completion of the logistic regression test, COVID 19 knowledge was found to be the most influential variable in COVID 19 preventative behavior (p = 0.000). When compared to those with good information, those with less understanding have a 16,101 times higher risk of misbehaving in preventing COVID 19 (Exp(B) 16,101).
Dyslipidemia is a condition of increasing levels of Low Density Lipoprotein (LDL), cholesterol in the blood, or triglycerides in the blood that can be accompanied by a decrease in levels of High Density Lipoprotein (HDL). Herbal products have been used since long ago in the medical world, one of which is curcuma longa root. The main compound of turmeric is curcumin which can lower cholesterol levels due to inhibiting cholesterol reabsorbtion from the outside and increase the enzyme HmgCoA reductase inhibitor so that fat synthesis can run properly. The purpose of this study was to find out the effectiveness of turmeric ethanol extract (Curcuma Longa) as an anti-dyslipidemia in male wistar rats given a high-fat diet. This experimental study with the pre-test and post-test group only control design approach was conducted in January 2021, at the Herbarium Medanese FMIPA USU. The size of the sample was calculated by Federer's formula, with at least 4 mice in each treatment group. The results and conclusions of turmeric ethanol (Curcuma Longa) III (150.20 ± 0.90 mg/dl) significantly decreased total cholesterol compared to the control group (177.50 ± 6.02mg/dl) (P value < 0.05). Turmeric ethanol extract (Curcuma Longa) III (110.00 (109-112) mg/dl) may significantly lower triglyceride levels compared to the control group (166.50 (160-175) mg/dl), (value P = 0.024). Turmeric ethanol extract (Curcuma Longa) III (66.50 ± 1.25 mg/dl) significantly lowered LDL levels compared to the control group (106.20 ± 3.50 mg/dl), (P value < 0.05). Turmeric ethanol extract (Curcuma Longa) III, (60.00 (59-61) mg/dl) can significantly increase HDL levels compared to the control group (27.00 (33-39) mg/dl), (Value P = 0.024). Turmeric ethanol extract (Curcuma Longa) III significantly lowered SGOT (Value = 0.024) and SGPT (Value P < 0.05) compared to the control group.
This study aims to determine the effect of bay leaf ethanol extract on the histopathological picture of the kidneys of rats induced by doxorubicin. To determine the administration of bay leaf ethanol extract is more effective in protecting the heart than the positive control (Vitamin E). The bay leaves used were obtained from the Harjosari II Medan Amplas area of Medan city. The independent variable in this study was Salam Leaf Ethanol Extract, while the dependent variable was kidney histopathology. This research was conducted at the Pharmacology and Toxicology Laboratory of the Faculty of Pharmacy, University of North Sumatra. The results showed that the administration of vitamin E together with doxorubicin showed a better renal histopathological picture. Vitamin E as a basic antioxidant is able to reduce the damage caused by doxorubicin which is seen in the absence of widening in the Bowman capsule.
Dyslipidemia is a major risk factor for atheroscler heart disease, stroke, and is often defined as abnormalities or disruption of lipid metabolism. Garcinia mangostana L. is famous for its anti-inflammatory properties and is used in the treatment of skin infections and wounds. The main phytochemicals present in this species are anisoprenylated xanthone, many reports of biological effects, such as antioxidant, pro-apoptosis, anti-proliferative, anti-nosiseptif, anti-inflammatory, neuroprotective, hypoglycemic, and anti-obesity. This study aims to find out the effectiveness of mangosteen peel ethanol extract as an anti-dyslipidemia in male wistar rats given a high-fat diet. This type of research is experimental with a Pre-test approach and Post-test group only control design. The samples used were mangosteen peel ethanol extract and male wistar rats, with the size of the sample calculated with Federer's formula. Analyze data with the One-Way Anova Test if the data is normally distributed with advanced tests in the form of Post Hoc Tukey HSD tests to see real differences between treatments. The results of the total cholesterol study in the entire treatment group of mice showed a significant difference in P values < 0.05. Triglyceride levels in the entire treatment group also showed significant differences, this can be seen from the value of P < 0.05 (Value P = 0.029). LDL levels also showed significant differences across the treatment group, which can be seen from the P value of < 0.05. HDL levels make a significant difference in the value of P < 0.05 (Value P = 0.029). SGOT and SGPT levels in the entire group of rat treatment showed significant differences, this was seen from the value of P < 0.05. The conclusion that mangosteen peel ethanol extract significantly lowered total cholesterol, triglyceride levels, LDL levels, SGOT levels compared to the control group. Mangosteen peel ethanol extract can significantly increase HDL levels compared to the control group.
Epidemiological studies show that nearly 20% of the world's population suffers from diseases related to allergies and asthma. The main compound of turmeric is curcumin has several pharmacological properties, antioxidant properties, anti-inflammatory, asthma treatment. The study aimed to determine the effects of ethanol extract Curcuma longa on the smooth muscle of the isolated guinea pigtic trachea in acetylcholine induction. This research method was experimental to observe the relationship of Curcuma longa ethanol extract (EECL) to the relaxing effects of isolated smooth muscle trachea marmot (tracheal ring chain) inserted into a bath organ filled with Kreb's physiological fluid by maintaining a temperature of 35-370C and associated with a Matlab recorder. Samples used by male guinea pigs and ethanol extract Curcuma longa (EECL). The results of the study that ethanol extract Curcuma longa has a relaxing effect on the smooth muscles of the trachea isolated from the experimental rats contracted with acetylcholine. Ethanol extract Curcuma longa has the ability not dising from theophylline 2 x 10-4 M in reducing smooth muscle contraction of insulated Cavia porcelain trachea induced by acetylcholine, acetylcholine strength without incubation contraction compared to acetylcholine with EECL incubation showed statistically different results (p <0.05). The mechanism of Curcuma longa relaxation effect on isolated guinea pig smooth muscle is mediated through inhibition of the enzyme PDE.
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