Typhoon Kalmaegi passed over an array of buoys and moorings in the northern South China Sea in September 2014, leaving a rare set of observations on typhoon‐induced dynamical and thermohaline responses in the upper ocean. The dynamical response was characterized by strong near‐inertial currents with opposite phases in the surface mixed layer and in the thermocline, indicating the dominance of the response by the excitation of the first baroclinic mode. The thermohaline response showed considerable changes in the mean fields in addition to a near‐inertial oscillation. In particular, temperature and salinity anomalies generally exhibited a three‐layer vertical structure, with the surface layer becoming cooler and saltier, the subsurface layer warmer and fresher, and the lower layer cooler and saltier again. The response in the surface and subsurface layers was much stronger to the right of the typhoon track, while that in the lower layer was stronger along the track and to the left. These features of the upper ocean response were grossly reproduced by a three‐dimensional numerical model. A model‐based heat budget analysis suggests that vertical mixing was mainly responsible for the surface cooling and subsurface warming, while upwelling was the cause of cooling from below. Both observations and model results indicate that the whole upper ocean experienced an overall cooling in the wake of typhoon Kalmaegi.

Myopia is prevalent worldwide, particularly in East and Southeast Asia. Recent studies have suggested that the spectral composition of ambient lighting in uences refractive development, especially in humans. We aimed to determine the effect of 650-nm single-wavelength red light on the inhibition of myopia progression in children. In this retrospective cohort study, 105 myopic children (spherical equivalent refractive error [SER], -6.75 to -1.00 dioptres (D)) aged from 4 to 14 years old were retrospectively reviewed. Subjects were treated with 650-nm, low-intensity, single-wavelength red light twice a day for 3 minutes each session, with at least a 4-hour interval between sessions. IOL Master was utilized to measure the axial length (AL) and corneal curvature. Choroidal images were assessed using enhanced depth imaging optical coherence tomography (EDI-OCT), and the luminal area (LA) and stromal area were converted to binary images by the Niblack method. At baseline, the mean SER was -3.09 ± 1.74 D and -2.87 ± 1.89 D at 9 months, and signi cant changes occurred over time (P = 0.019). The AL increased by -0.06 ± 0.19 mm for 9 months (0.21 ± 0.15 mm pretreatment; P 0.001). The subfoveal choroidal thickness (SFChT) had changed by 45.32 ± 30.88 μm at the 9-month examination (P 0.001).Repetitive exposure to 650-nm, low-intensity, single-wavelength red light effectively slowed the progression of myopia and reduced axial growth after short treatment durations. These results require further validation in a longitudinal study, as well as further research in animal models.

To determine whether photobiomodulation (PBM) therapy can retard ocular axial length (AL) in children with myopia. A randomized controlled clinical trial was conducted on two consecutive cohorts of 50 eligible children aged 8–12 years with ≤ − 0.75 Diopter (D) of spherical equivalent refraction (SER). Participants were randomly assigned to the intervention group (n = 25) and treated with PBM therapy or the control group (n = 25) and treated with single vision spectacles only. At the 12-month follow-up, the changes in AL and cycloplegic SER from baseline were both compared between the two groups. In addition, the subfoveal choroidal thickness (SFChT), anterior chamber depth (ACD), and central corneal refractive power (CCP) were analysed at the 3-, 6-, 9-, and 12-month follow-ups, respectively. Among the 50 children, 78% were included at the final follow-up, with a mean age of 9.7 ± 1.5 years and a mean SER of − 2.56 ± 1.70. The mean difference in AL growth between the two groups at 12 months was 0.50 mm (PBM vs. Control, − 0.02 mm ± 0.11 vs. 0.48 mm ± 0.16, P < 0.001), and the mean difference in cycloplegic SER at 12 months was + 1.25 D (PBM vs. Control, + 0.28 D ± 0.26 vs. − 0.97 D ± 0.25, P < 0.001). There were no significant differences in any of the other parameters (including SFChT, ACD, and CCP) between the two groups at any time point. PBM therapy is an effective intervention for slightly decreasing the AL to control myopia in children.Trial registration: Chinese Clinical Trial Registration Number: ChiCTR2100043619. Registered on 23/02/2021; prospectively registered. http://www.chictr.org.cn/showproj.aspx?proj=121302.

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