Myopia is prevalent worldwide, particularly in East and Southeast Asia. Recent studies have suggested that the spectral composition of ambient lighting in uences refractive development, especially in humans. We aimed to determine the effect of 650-nm single-wavelength red light on the inhibition of myopia progression in children. In this retrospective cohort study, 105 myopic children (spherical equivalent refractive error [SER], -6.75 to -1.00 dioptres (D)) aged from 4 to 14 years old were retrospectively reviewed. Subjects were treated with 650-nm, low-intensity, single-wavelength red light twice a day for 3 minutes each session, with at least a 4-hour interval between sessions. IOL Master was utilized to measure the axial length (AL) and corneal curvature. Choroidal images were assessed using enhanced depth imaging optical coherence tomography (EDI-OCT), and the luminal area (LA) and stromal area were converted to binary images by the Niblack method. At baseline, the mean SER was -3.09 ± 1.74 D and -2.87 ± 1.89 D at 9 months, and signi cant changes occurred over time (P = 0.019). The AL increased by -0.06 ± 0.19 mm for 9 months (0.21 ± 0.15 mm pretreatment; P 0.001). The subfoveal choroidal thickness (SFChT) had changed by 45.32 ± 30.88 μm at the 9-month examination (P 0.001).Repetitive exposure to 650-nm, low-intensity, single-wavelength red light effectively slowed the progression of myopia and reduced axial growth after short treatment durations. These results require further validation in a longitudinal study, as well as further research in animal models.
To determine whether photobiomodulation (PBM) therapy can retard ocular axial length (AL) in children with myopia. A randomized controlled clinical trial was conducted on two consecutive cohorts of 50 eligible children aged 8–12 years with ≤ − 0.75 Diopter (D) of spherical equivalent refraction (SER). Participants were randomly assigned to the intervention group (n = 25) and treated with PBM therapy or the control group (n = 25) and treated with single vision spectacles only. At the 12-month follow-up, the changes in AL and cycloplegic SER from baseline were both compared between the two groups. In addition, the subfoveal choroidal thickness (SFChT), anterior chamber depth (ACD), and central corneal refractive power (CCP) were analysed at the 3-, 6-, 9-, and 12-month follow-ups, respectively. Among the 50 children, 78% were included at the final follow-up, with a mean age of 9.7 ± 1.5 years and a mean SER of − 2.56 ± 1.70. The mean difference in AL growth between the two groups at 12 months was 0.50 mm (PBM vs. Control, − 0.02 mm ± 0.11 vs. 0.48 mm ± 0.16, P < 0.001), and the mean difference in cycloplegic SER at 12 months was + 1.25 D (PBM vs. Control, + 0.28 D ± 0.26 vs. − 0.97 D ± 0.25, P < 0.001). There were no significant differences in any of the other parameters (including SFChT, ACD, and CCP) between the two groups at any time point. PBM therapy is an effective intervention for slightly decreasing the AL to control myopia in children.Trial registration: Chinese Clinical Trial Registration Number: ChiCTR2100043619. Registered on 23/02/2021; prospectively registered. http://www.chictr.org.cn/showproj.aspx?proj=121302.
Myopia is prevalent worldwide, particularly in East and Southeast Asia. Recent studies have suggested that the spectral composition of ambient lighting influences refractive development, especially in humans. We aimed to determine the effect of 650-nm single-wavelength red light on the inhibition of myopia progression in children. In this retrospective cohort study, 105 myopic children (spherical equivalent refractive error [SER], -6.75 to -1.00 dioptres (D)) aged from 4 to 14 years old were retrospectively reviewed. Subjects were treated with 650-nm, low-intensity, single-wavelength red light twice a day for 3 minutes each session, with at least a 4-hour interval between sessions. IOL Master was utilized to measure the axial length (AL) and corneal curvature. Choroidal images were assessed using enhanced depth imaging optical coherence tomography (EDI-OCT), and the luminal area (LA) and stromal area were converted to binary images by the Niblack method. At baseline, the mean SER was -3.09 ± 1.74 D and -2.87 ± 1.89 D at 9 months, and significant changes occurred over time (P = 0.019). The AL increased by -0.06 ± 0.19 mm for 9 months (0.21 ± 0.15 mm pretreatment; P<0.001). The subfoveal choroidal thickness (SFChT) had changed by 45.32 ± 30.88 μm at the 9-month examination (P<0.001). Repetitive exposure to 650-nm, low-intensity, single-wavelength red light effectively slowed the progression of myopia and reduced axial growth after short treatment durations. These results require further validation in a longitudinal study, as well as further research in animal models.
Purpose
To investigate the inhibitory effect of bendazol on form‐deprivation myopia (FDM) in rabbits as well as the underlying biochemical processes.
Methods
Forty‐eight 3‐week‐old New Zealand white rabbits were randomly assigned to three groups: a control group, a form‐deprivation (FD) group and an FD + bendazol group (treated with 1% bendazol in the FD eyes). Refraction, corneal curvature, vitreous chamber depth (VCD) and axial length (AL) were assessed using streak retinoscopy, keratometry, and A‐scan ultrasonography, respectively. Eyeballs were enucleated for histological analysis, and ocular tissues were homogenized to determine the mRNA and protein expression of hypoxia‐inducible factor‐1α (HIF‐1α) and muscarinic acetylcholine receptors (mAChRs).
Results
Bendazol inhibited the progression of FDM and suppressed the upregulation of HIF‐1α. At week 6, in the control, FD and FD + bendazol groups, the refraction values were 1.38 ± 0.43, 0.03 ± 0.47 and 1.25 ± 0.35 D, respectively (p < 0.001); the ALs were 13.91 ± 0.11, 14.15 ± 0.06 and 13.97 ± 0.10 mm, respectively (p < 0.001) and the VCDs were 6.56 ± 0.06, 6.69 ± 0.07 and 6.61 ± 0.06 mm, respectively (p < 0.001). HIF‐1α was upregulated in FD eyes but downregulated in FD + bendazol eyes, while the mAChRs were the opposite.
Conclusions
In the FD rabbit model, bendazol significantly inhibits the development of myopia and downregulates HIF‐1α expression, which may provide a novel therapeutic approach for myopia control.
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