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The effect was evaluated in puppies and adult dogs by measuring the rate of passage of radioactive iodinated human serum albumin from plasma into the cerebrospinal fluid and by determining the plasma and cerebrospinal fluid glutamic oxalacetic transaminase and lactic dehydrogenase activities. Arterial O2 concentration and saturation, CO2, and pH determinations were obtained. In puppies, hypercapnia was associated with marked respiratory acidosis and produced a great increase in the rate of transfer of albumin I131 from plasma to cerebrospinal fluid. Prolonged hypoxia also produced a definite increase in permeability of the blood-cerebrospinal fluid barrier. Increased concentration ratios of cerebrospinal fluid enzyme activity/plasma enzyme activity were observed in both groups. Hypoxia alone did not cause significant changes. In adult dogs, hypercapnia or hypoxia did not result in comparable findings.

Two cases are reported in which symptomatic lead poisoning coincided with normal haemoglobin concentrations and blood lead levels below 80 [Lg/100 ml.Urinary coproporphyrins and amino laevulinic acid concentrations were elevated. These latter tests are useful for confirmation of clinical diagnoses and for the screening of industrial lead workers.

stated (referring to the sulfonamide drugs) "these risks should be taken in view of the danger of repeated insults to the heart." " In addition, it is imperative that in any prophylactic method which conceivably would be used for successive months, if not years, the procedure be as simple as possible for the lay person to follow. In this instance the schedule followed during the third year of this study conforms to this requirement, for the parent can easily remember to give the tablets of penicillin orally before meals and at bedtime during the first week of every month. SUMMARY A feasible schedule of oral administration of penicillin consisting of 800,000 units daily for seven consecutive days the first week of each month throughout the school year has been shown to be effective in significantly reducing the incidence of hemolytic streptococcic infections in the throats of children who have had rheumatic fever.

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The effect of prolonged convulsions (induced by Metrazol or electroshock) on the blood-cerebrospinal fluid barrier of puppies was evaluated with the use of radioiodinated human serum albumin by measuring its rate of passage from the plasma into the cerebrospinal fluid. Albumin I131 was injected intravenously and convulsions were induced immediately by intravenous Metrazol or the application of electroshock. A marked increase in the concentration ratio (cerebrospinal fluid radioactivity/ plasma radioactivity) occurred when seizures were maintained for 30 minutes or longer. The slope of cerebrospinal fluid albumin I131 concentration as a function of time was about 25 times as great in the convulsed puppies as in the controls. It is concluded that marked alteration in the permeability of the blood-cerebrospinal fluid barrier to albumin I131 was produced by prolonged seizures.

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