Treatment of Nephrotic Syndrome with Interrupted ACTH or Oral Cortisone Therapy.

Lange, Kurt; Slobody, Lawrence B.; Strang, Ruth

doi:10.3181/00379727-82-20104

Cited by 24 publications

(11 citation statements)

References 1 publication

(1 reference statement)

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“…This regimen of uninterrupted therapy is continued for about two to three years, and at present seems the more preferable. 3. Triamcinolone is a useful addition to our armamentarium of treatment for idiopathic nephrosis of childhood.…”

Section: F~~~:iplicateit~~vs' Of Therapymentioning

confidence: 99%

Treatment of the Uncomplicated Nephrotic Syndrome in Children with Triamcinolone: a Six-Year Study

Sonnenschein

Minsky

Krämer

1964

Clin Pediatr (Phila)

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TIE tiel)lirotic syndrome is a disease, the cause of which is unknown, the treatment unsatisfactory, and the prognosis uncertain. The uncomplicated nephrotic syndrome in children is characterized by the presence of edema, hypoproteinemia, hyperlipemia, and proteinuria, and by the absence of persistent hypertension, azotemia and gross hematuria. The more complicated forms include neonatal or infantile nephrosis, nephrosis superimposed upon severe diabetes, and the nephropathies of syphilis, amyioidosis, disseminated lupus erythematosus., and acute and chronic glomerulonephritis.The introduction of antibiotics has eliminated almost completely the secondary serious infections such as primary streptococcal or pneumococcal peritonitis and the migrating erysipelas which took such a large toll in pre-antibiotic days. In nearly all cases the giving of steroids reverses the clinical and the chemical findings that characterize the disease, and has made it possible for most patients to live a normal life in spite of occasional mild proteinuria. Thus, morbidity has decreased while the matter of survival remains an open question.The side reactions from cortisone and ACTH, some quite distressing, have stimulated a search for more effective synthetic steroids-among them hydrocortisone, fluorohydrocortisone, Ai fluorohydrocortisone and Ai-9 alpha fluara-I6 alpha hydroxy-hydrocortisone (triamcinolone). Studies by Hellman et aU with triamcinolone in chronic arthritis were suggestive of a favorable therapeutic effect without the unfavorable reactions of other steroids. The absence of fluid and sodium retention and potassium depletion was stressed specifically. This finding suggested to Hellman eat al. the use of triamcinolone in 15 children suffering from the nephrotic syn-* Attending Pediatrician, Maimonides Hospital;

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Section: F~~~:iplicateit~~vs' Of Therapymentioning

confidence: 99%

Treatment of the Uncomplicated Nephrotic Syndrome in Children with Triamcinolone: a Six-Year Study

Sonnenschein

Minsky

Krämer

1964

Clin Pediatr (Phila)

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“…They increase renal blood flow in patients with hypertensive vascular diseases. ACTH causes diuresis and general clinical improvement of the nephrotic syndrome (Lange et al, 1953). In man, cortisol enhances the renal clearance of salicylate, most probably through increased glomerular filtration and diminished tubular reabsorption (Klinenberg & Miller, 1965).…”

Section: ) Organ Structure and Functionmentioning

confidence: 99%

Effect of ACTH, corticoids and PCN (pregnenolone-16α-carbonitrile) on drug responses and disposition

Szabó¹

1979

Acta Endocrinologica

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The endocrine system plays an important role in the adaptation of the organism to environmental stimuli: it influences both specific and nonspecific responses. The ,,emergency reaction" and the ,,stress syndrome" were recognized a long time ago, but they remain very complex processes. Elucidation of their mechanism(s) of action is difficult, and the importance of individual hormones is not yet clearly understood. extracts and corticosterone, but not by DOC (Jensen & Grattan, 1940).

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“…Observed and expected changes occurring with diuresis include increases in glomerular filtration rate (102,108), serum complement (104,109,110,111), and serum albumin (112,113); decrease in salt-retaining substances in urine (114,115,116), in antidiuretic activity of blood (114,115,116) and urine (117), and in glomerular permeability to albumin (117,118); and return toward normal excretion of sodium and potassium (119,120). Hypo electrolyte mia, convulsions, and increased risk of infections constitute the major hazards of hormone therapy (105,121,122,123).…”

Section: Renal Diseasementioning

confidence: 99%

Pediatrics

Platou¹

1956

Annu. Rev. Med.

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Treatment of Nephrotic Syndrome with Interrupted ACTH or Oral Cortisone Therapy.

Cited by 24 publications

References 1 publication

Treatment of the Uncomplicated Nephrotic Syndrome in Children with Triamcinolone: a Six-Year Study

Treatment of the Uncomplicated Nephrotic Syndrome in Children with Triamcinolone: a Six-Year Study

Effect of ACTH, corticoids and PCN (pregnenolone-16α-carbonitrile) on drug responses and disposition

Pediatrics

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