Agranulocytosis of the Newborn Infant

Abstract

stated (referring to the sulfonamide drugs) "these risks should be taken in view of the danger of repeated insults to the heart." " In addition, it is imperative that in any prophylactic method which conceivably would be used for successive months, if not years, the procedure be as simple as possible for the lay person to follow. In this instance the schedule followed during the third year of this study conforms to this requirement, for the parent can easily remember to give the tablets of penicillin orally before meals and at bedtime during the first week of every month. SUMMARY A feasible schedule of oral administration of penicillin consisting of 800,000 units daily for seven consecutive days the first week of each month throughout the school year has been shown to be effective in significantly reducing the incidence of hemolytic streptococcic infections in the throats of children who have had rheumatic fever.

NB1, a new neutrophil-specific antigen involved in the pathogenesis of neonatal neutropenia

“…family, shown in Fig. 1 A, was the subject of reports by Slobody, Abramson, and Loiseaux (7), Lehndorff (8), and Luhby and Slobody (9). Both newborns were affected.…”

Neonatal Alloimmune Neutropenia

“…After several reports [1,2] of siblings suspected for immune mediated agranulocytosis in the 1950s, it was in 1960 that Lalezari et al [3] first proved the presence of maternal antibodies causing severe neutropenia (complete absence of granulocytes) in three of four siblings and named the disorder ‘isoimmune neonatal neutropenia'. Unfortunately, the first child died of pneumonia.…”

Infantile Congenital Aneutrocytosis

“…Transitory granulocytopenia of the newborn was described by Slobody, Abramson and Loizeaux (1950) and Lehndorff (1951). In this condition there is a pronounced granulocytopenia with a duration of several days up to four weeks.…”