The effect was evaluated in puppies and adult dogs by measuring the rate of passage of radioactive iodinated human serum albumin from plasma into the cerebrospinal fluid and by determining the plasma and cerebrospinal fluid glutamic oxalacetic transaminase and lactic dehydrogenase activities. Arterial O2 concentration and saturation, CO2, and pH determinations were obtained. In puppies, hypercapnia was associated with marked respiratory acidosis and produced a great increase in the rate of transfer of albumin I131 from plasma to cerebrospinal fluid. Prolonged hypoxia also produced a definite increase in permeability of the blood-cerebrospinal fluid barrier. Increased concentration ratios of cerebrospinal fluid enzyme activity/plasma enzyme activity were observed in both groups. Hypoxia alone did not cause significant changes. In adult dogs, hypercapnia or hypoxia did not result in comparable findings.
The effect of prolonged convulsions (induced by Metrazol or electroshock) on the blood-cerebrospinal fluid barrier of puppies was evaluated with the use of radioiodinated human serum albumin by measuring its rate of passage from the plasma into the cerebrospinal fluid. Albumin I131 was injected intravenously and convulsions were induced immediately by intravenous Metrazol or the application of electroshock. A marked increase in the concentration ratio (cerebrospinal fluid radioactivity/ plasma radioactivity) occurred when seizures were maintained for 30 minutes or longer. The slope of cerebrospinal fluid albumin I131 concentration as a function of time was about 25 times as great in the convulsed puppies as in the controls. It is concluded that marked alteration in the permeability of the blood-cerebrospinal fluid barrier to albumin I131 was produced by prolonged seizures.
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