Recurrent PU runs in the presence of calcium-regulating system dysfunction. Incorporation of the thyroid C-cell hormone preparation calcitrin, the slow calcium-channel blocker nifedipine, and etidronic acid bisphosphonate into a complex of treatment for a disease recurrence is pathogenetically sound and clinically effective.
СOVID-19 is a systemic disease with dysfunction of the immune system and damage to internal organs, including the liver. The purpose of the study is to fnd out the impact of the SARS-CoV-2 virus on the liver, the possibility of its recovery after a coronavirus infection. We examined 112 patients with a positive test for COVID-19. А clinical examination, clinical and biochemical blood tests, computed tomography of the chest, pulse oximetry, ultrasound examination of the abdomen were performed. All patients were divided into two groups based on the presence or the absence of cytolytic syndrome. It was found that liver pathology was detected in 48.2% of patients. These changes were accompanied by statistically signifcant lower levels of oxygen in the blood and a greater amount of damage to the lung tissue, disorders of the platelet germ of hematopoiesis. Three months after a coronavirus infection with liver damage, a third of patients had cytolysis syndrome. The use of ademetionine at a dose of 800–1600 mg per day led to the elimination of clinical symptoms, normalization of the liver.Conclusion. Liver damage during coronavirus infection was common and had a hepatocellular nature, accompanied by hypoxia, increased lung tissue damage and changes in platelet count. Patients need to be examined to identify the presence of liver pathology, treatment of disorders using ademetionine.
Recurrence of peptic ulcer disease, its comorbid with arterial hypertension is accompanied by calcium-phosphorus imbalance, contributing to the increase of acid-peptic factor, the changes of motor function of the stomach, regional microcirculation, activation of the ulcer process. The use of nifedipine in the therapy of comorbid peptic ulcer disease and arterial hypertension, contributes to the restoration of calcium-phosphorus balance, gastric functions and regional microcirculation, reduces the time and increases the frequency of scarring of ulcers.
Aim. To evaluate the state of bone tissue in comparison with calcium balance, to clarify the risk for fracture development in women of different age groups. METHODS. 92 females aged 19 to 89 years were examined clinically with densitometry of lumbar spine and femoral neck and measuring the concentration of total calcium in the blood. RESULTS. In females younger than 50 years decreased bone density according to Z-score was revealed in 30% of cases, among patients with its normal values significant trend to bone rarefaction (-2.0 SD <Z-score ≤-1.5 SD) was registered with the same rate. In the group of females older than 50 years osteopenia was revealed in 46.3% of cases and osteoporosis - in 42.7%, while more significant decrease in bone mineral density was found in the lumbar spine. Past medical history of fractures increased the rate of osteoporosis by 18%. In females older than 50 years compared to younger patients a significant increase of blood calcium concentration was revealed. Besides, statistically significant increase of its level was noted in cases of fractures in the past and osteoporosis. The revealed changes of bone tissue in females below 50 years of age are indicative of increased risk of osteoporosis development in the future. CONCLUSION. High prevalence of osteoporosis and osteopenia is revealed in the examined patients older than 50 years, and bone mineral density parameters were significantly inversely correlated with calcemia; hence, blood calcium level can be one of the criteria of bone tissue state and in combination with other risk factors for osteoporosis should be taken into account during periodic health examination of females older than 50 years.
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