The calcium-regulating system and recurrent peptic ulcer

Chernin, V V; Fomina, L. A.

doi:10.17116/terarkh201688210-15

Cited by 9 publications

(5 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although studies reporting the effect of calcium on the increase in gastric acidity are intense (2)(3)(4)7,8), other literature reports focus on either increased pepsinogen (3,7) or increased gastrin levels (2,9,10 (12). In contrast, we had no mortalities.…”

Section: Discussionmentioning

confidence: 52%

“…The stomach also counteracts the harmful effects of acid and pepsin, the protective effects of prostaglandins, mucus secretions, saliva, food intake, HCO 3 and duodenal content. When this balance is degraded in favour of acid, the risk of developing PU increases.…”

Section: Introductionmentioning

confidence: 99%

“…Few years ago, Pawlow's research began to explore the relationship between blood calcium level and PU (2). Increased serum calcium levels have been shown to increase gastrin, gastric acid and pepsinogen secretions by both direct and indirect effects (2)(3)(4)(5). We aimed to reveal the difference in the blood values of calcium in the aetiology of PU in patients who were diagnosed with PU in the upper gastrointestinal tract by endoscopy performed electively with a diagnosis of peptic ulcer perforation (PUP) in our emergency department.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Do elevated blood calcium levels in patients with peptic ulcer facilitate perforation?

Kahramanca¹,

Anuk²,

Yıldırım³

2018

J Turgut Ozal Med Cent

View full text Add to dashboard Cite

Aim: Calcium is primarily stored in bones in the body. The increase in blood calcium level due to primary or secondary causes leads to several impairments of the gastrointestinal system like nausea-vomiting, and peptic ulcer (PU). In this study, we want to compare and analyse the difference in blood calcium levels of patients who underwent surgery for peptic ulcer perforation (PUP) and were diagnosed with PU by endoscopy. Material and Methods: Between May 2012-January 2017, patients' data for PU disease were recorded and our study was planned retrospectively. Patients were seperated into two groups: Group1, who was operated for PUP; and Group2, who were administered medical therapy for PU. Blood calcium levels during admission, age, gender and drug history of patients were recorded. Study exclusion criteria were patients whose data were missing (n=113), patients who had metabolic bone disease, patients who had been using calcium channel blockers and who were administered anti-ulcer drugs. Results: Twenty-eight patients had PUP and 176 patients had PU disease. Group 1 had a lower mean age (p=0.017), and higher male gender rate (p<0.001). The mean calcium level of Group 1 was 9.7±0.6 mg/dl, while the mean calcium level of Group 2 was 8.8±0.7 mg/dl (p<0.001). Less than the cut-off value of 9.25, calcium showed a sensitivity of 78.6% and a specificity value of 73.1% between groups. Conclusion: In our study, we found that in patients with PU diagnoses, elevated levels of calcium found in controls may increase both stomach acidity and the risk of PUP.

show abstract

Section: Discussionmentioning

confidence: 52%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Do elevated blood calcium levels in patients with peptic ulcer facilitate perforation?

Kahramanca¹,

Anuk²,

Yıldırım³

2018

J Turgut Ozal Med Cent

View full text Add to dashboard Cite

show abstract

“…Предыдущими нашими исследованиями показано, что рецидив ЯБ протекает на фоне увеличения активности паращитовидных желез с повышением секреции паратириоидного гормона, который способствует активации кислото-пептического фактора, изменению моторной активности гастродуоденальной зоны (ГДЗ), оказывает разрушающее действие на ее слизистую оболочку (СО). Рубцевание язвы происходит при усилении саногенных механизмов и сопровождается активацией С-клеток щитовидной железы с повышением выработки кальцитонина [8]. Гормоны КРС кроме прямого воздействия на состояние ГДЗ [9,10,11] вызывают опосредованное влияние, изменяя кальциево-фосфорный метаболизм, также оказывающий влияние на морфо-функциональное состояние ГДЗ [12,13,14].…”

Section: Introductionunclassified

Hypercalcemia as a marker of decreased bone mineral density in patients with peptic ulcer disease

Fomina

Фомина

Chernin

2021

jour

Self Cite

View full text Add to dashboard Cite

Purpose of the study. To study calcium-phosphorus metabolism in patients with peptic ulcer (PU) in comparison with bone mineral density (BMD), its age and gender aspects. Materials and methods. 216 people with ulcer were in remission and 154 people without ulcer history and erosive-ulcerative changes during fibrogastroduodenoscopy (FGDS) were examined. All patients underwent clinical and endoscopic studies, dichromatic X-ray densitometry with the calculation of the T-test of the femoral neck (FN) and the lumbar spine (LS). Calcium and blood phosphorus have been studied. Results. In patients with PU compared with patients without this pathology there was a significant decrease of BMD. In 32% of patients with PU osteoporosis (OP) was diagnosed and in 34% of patients - osteopenia. In the group of persons who had no PU osteoporosis was found in 18%, osteopenia in 26% of cases. In both groups women prevailed. Blood calcium was significantly higher in patients with PU as compared to those examined without an ulcer history. A significant increase of calcium was observed in individuals with a comorbid course of PU and OP. Conclusion. The data obtained show that the study of blood calcium can serve as a simple criterion for diagnosing disorders of BMD and, if its values are high, conduct a more detailed examination of patients with PU for early detection of OP and the possibility of its treatment.

show abstract

“…Осмысление прямых и обратных связей при взаимодействии биологических агентов разной природы, участвующих в развитии патологических процессов и противодействии им, давало основания для разработки и совершенствования концепции активизации функциональных блоков, регулирующих морфофункциональное состояние эзофагогастродуоденальной зоны. В частности, с этих позиций обсуждалась роль кальцийрегулирующей системы, системы гистамин-гистаминаза-гистаминопексия, сегментарно-периферического и надсегментарного отделов вегетативной нервной системы [3,4,5].…”

unclassified

“When i take stock of my life lived…” (In memory of professor Vyacheslav Vasilievich Chernin)

Dzhulay

2022

jour

View full text Add to dashboard Cite

Цель исследования. Проанализировать в мемориальной статье эволюцию научных идей одного из ярких представителей Российской научной школы гастроэнтерологов -профессора В. В. Чернина (1935-2021).Материалы и методы. Критически оценены основные труды В. В. Чернина и его сотрудников, включая монографии, руководства для врачей, публикации в научных журналах.Результаты. Рассмотрены основные результаты научной деятельности В. В. Чернина при исследовании заболеваний верхних отделов пищеварительного тракта -язвенной болезни и ее осложнений, вариантов хронического гастрита и эзофагита. Патологические состояния пищеварения рассматривались им с позиций нейроэндокринной регуляции функций эзофагогастродуоденальной зоны, причинно-следственных взаимоотношений структуры и функции органов пищеварительного тракта, комбинации патогенетических и саногенных реакций, микробиоценозов мукозной флоры.Ключевые слова: язвенная болезнь, хронический гастрит, эзофагит, патогенез и саногенез, нейроэндокринная регуляция функций, микробиоценоз мукозной микрофлоры Конфликт интересов. Автор заявляет об отсутствии конфликта интересов.

show abstract

The calcium-regulating system and recurrent peptic ulcer

Cited by 9 publications

References 1 publication

Do elevated blood calcium levels in patients with peptic ulcer facilitate perforation?

Do elevated blood calcium levels in patients with peptic ulcer facilitate perforation?

Hypercalcemia as a marker of decreased bone mineral density in patients with peptic ulcer disease

“When i take stock of my life lived…” (In memory of professor Vyacheslav Vasilievich Chernin)

Contact Info

Product

Resources

About