Liver pathology in COVID-19

Abstract

СOVID-19 is a systemic disease with dysfunction of the immune system and damage to internal organs, including the liver. The purpose of the study is to fnd out the impact of the SARS-CoV-2 virus on the liver, the possibility of its recovery after a coronavirus infection. We examined 112 patients with a positive test for COVID-19. А clinical examination, clinical and biochemical blood tests, computed tomography of the chest, pulse oximetry, ultrasound examination of the abdomen were performed. All patients were divided into two groups based on the presence or the absence of cytolytic syndrome. It was found that liver pathology was detected in 48.2% of patients. These changes were accompanied by statistically signifcant lower levels of oxygen in the blood and a greater amount of damage to the lung tissue, disorders of the platelet germ of hematopoiesis. Three months after a coronavirus infection with liver damage, a third of patients had cytolysis syndrome. The use of ademetionine at a dose of 800–1600 mg per day led to the elimination of clinical symptoms, normalization of the liver.Conclusion. Liver damage during coronavirus infection was common and had a hepatocellular nature, accompanied by hypoxia, increased lung tissue damage and changes in platelet count. Patients need to be examined to identify the presence of liver pathology, treatment of disorders using ademetionine.

Features of the course of liver cirrhosis in the background of infection with COVID-19

“…Reimer 1 1 Novosibirsk State Medical University, (52, Krasny prospect, Novosibirsk, 630091, Russia) 2 City Clinical Hospital No. 1, (6,st. Zalessky,Novosibirsk,630047,Russia) https://doi.org /10.31146/1682-8658-ecg-212-4-64-69 Манифестация в декабре 2019 года инфекции, обусловленной вирусом SARS-CoV-2 (Severe acute respiratory syndrome-related coronavirus-2), стала причиной пандемии COVID-19 (Corona Virus Disease 2019), которая предвнесла в медицинскую практику многих стран, в том числе и Российкой Федерации, существенные проблемы.…”

“…Практически у половины пациентов даже при отсутствии патологии печени может наблюдаться возникновение и прогрессирование цитолитического синдрома, гипопротеинемия, нарушение показателей гемостаза, в частности увеличение протромбинового времени. В частности, у 60% пациентов на фоне инфекции COVID-19 вирус SARS-CoV-2 был об-наружен в ткани печени [5,6]. Также установлено, что коронавирусная инфекция, вызванная вирусом SARS-CoV-2 может вызывать прогрессирование хронических заболеваний печени [7,8].…”