Gender aspects of osteoporosis and their relationship to calcium balance

Fomina, L. A.; Артуровна, Фомина Людмила; Zyabreva, I A; Андреевна, Зябрева Ирина

doi:10.17750/kmj2017-343

Cited by 4 publications

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“…Для ОП, протекающего с изменением структуры костной ткани и снижением ее минеральной плотности, характерны изменения в системе кальцийрегулирующих гормонов и кальциево-фосфорном балансе. [16,17,18].…”

Section: Introductionunclassified

Hypercalcemia as a marker of decreased bone mineral density in patients with peptic ulcer disease

Fomina

Фомина

Chernin

2021

jour

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Purpose of the study. To study calcium-phosphorus metabolism in patients with peptic ulcer (PU) in comparison with bone mineral density (BMD), its age and gender aspects. Materials and methods. 216 people with ulcer were in remission and 154 people without ulcer history and erosive-ulcerative changes during fibrogastroduodenoscopy (FGDS) were examined. All patients underwent clinical and endoscopic studies, dichromatic X-ray densitometry with the calculation of the T-test of the femoral neck (FN) and the lumbar spine (LS). Calcium and blood phosphorus have been studied. Results. In patients with PU compared with patients without this pathology there was a significant decrease of BMD. In 32% of patients with PU osteoporosis (OP) was diagnosed and in 34% of patients - osteopenia. In the group of persons who had no PU osteoporosis was found in 18%, osteopenia in 26% of cases. In both groups women prevailed. Blood calcium was significantly higher in patients with PU as compared to those examined without an ulcer history. A significant increase of calcium was observed in individuals with a comorbid course of PU and OP. Conclusion. The data obtained show that the study of blood calcium can serve as a simple criterion for diagnosing disorders of BMD and, if its values are high, conduct a more detailed examination of patients with PU for early detection of OP and the possibility of its treatment.

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Section: Introductionunclassified

Hypercalcemia as a marker of decreased bone mineral density in patients with peptic ulcer disease

Fomina

Фомина

Chernin

2021

jour

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The effect of internal course intake of selenium-modified mineral water on bone mineral density after long-term diet-induced metabolic disorders in the experiment. (Randomized controlled trial)

Kaisinova,

Abramtsova,

Uzdenov

et al. 2023

Vopr. kurortol. fizioter. lech. fiz. kul't.

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Comorbid for gastroduodenal ulcers in the aspect of calcium imbalance and blockers of slow calcium channels in their treatment

Fomina

2018

Terapevticheskii arkhiv

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Improvement of methods of prevention and treatment led to an increase in the number of patients with comorbid occurring chronic disease that requires effective integrated therapy to reduce the polypharmacy. Aim. Find out the calcium content of the blood reflecting its balance and functional status the calcium regulatory system when it is comorbid for gastroduodenal ulcers (GDU), developed on the background of chronic erosive gastritis (CEG), chronic erosive duodenitis (CED), arterial hypertension (AH) and osteo-articular pathology with the use of nonsteroidal anti-inflammatory drugs (NSAIDs), and the impact of his changes on the activity ulzerogennogo process, the state of regional microcirculation and the functions of the stomach. To determine the pathogenetic justification for and effectiveness of blockers of slow calcium channels (BSCaC) in complex treatment. Materials and methods. Examined 132 patients with GDU. All patients were divided into groups: the 1st (n=49) - patients with recurrent of peptic ulcer disease (PUD) and CEG/CED; the 2nd (n=23) - with recurrence of PUD and AH, the 3rd (n=14) - with GDU and osteoarticular pathology, taking NSAIDs. Patients of these three groups for the treatment of erosive ulcerous lesions of gastroduodenal zone (GDZ) has been appointed complex therapy with inclusion of nifedipine. The 4th (control) group consisted of 56 patients with recurrent BU without concomitant pathology, applying integrated therapy with nifedipine. The results and discussion. The PU relapse, comorbid her over with erosive gastroduodenitis, hypertension, GDU with of osteoarticular pathology and taking NSAIDs is accompanied by a calcium imbalance with increased levels of calcium in the blood, contributing to increase of acid-peptic factor in the formation of hypermotor dyskinesia stomach, disruption of regional microcirculation and repair processes, activation of ulcerogenesis in GDZ. Inclusion in the complex therapy of GDU of nifedipine leads to the recovery of calcium balance, functions of the stomach and regional microcirculation, accelerates the timing and increases the percentage of scarring ulcers. Conclusion. GDU accompanied by dysfunction the calcium regulatory system with increasing levels of blood calcium, contributing to the formation of the major pathogenetic mechanisms of ulcerogenesis. BSCaC application in complex therapy of GDU is pathogenetically justified and clinically effective, reduces the excessive drug treatment in the treatment.

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Gender aspects of osteoporosis and their relationship to calcium balance

Cited by 4 publications

References 0 publications

Hypercalcemia as a marker of decreased bone mineral density in patients with peptic ulcer disease

Hypercalcemia as a marker of decreased bone mineral density in patients with peptic ulcer disease

The effect of internal course intake of selenium-modified mineral water on bone mineral density after long-term diet-induced metabolic disorders in the experiment. (Randomized controlled trial)

Comorbid for gastroduodenal ulcers in the aspect of calcium imbalance and blockers of slow calcium channels in their treatment

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