Background problem associated with health problems such as metabolic syndrome, diabetes mellitus and cardiovascular disease. A low-grade chronic inflammatory state, reflected by decreased with obesity. Objective in obese and normal weight children. Methods We conducted a cross-sectional, case-controlled study We performed physical examinations, measured blood pressure, weight and height, and calculated BMI for all subjects. After an overnight fast, all subjects were tested for fasting blood glucose, Results The mean adiponectin level in the obese group was 3.6 Conclusions obese group is consistent with a low-grade chronic inflammatory further evaluation. Early intervention is needed to reduce body weight in obese children. [Paediatr Indones. 2011;51:7-11].
Background Acanthosis nigricans (AN) is a skin condition characterized by darkening and thickening of skin. AN has been reported to be linked to insulin resistance (IR), that associated with type 2 diabetes, in obese children in many country.Objective To determine the relation between acanthosis nigricans and insulin resistance in obese children.Methods We conducted a cross sectional study in Wenang District, Manado, from October 2009 until January 2010. We examined 54 obese children aged 10-14 years for insulin resistance using Homeostasis Model Assessment of Insulin Resistance Index (HOMA-IR). We analyzed the results byT-test and phi coefficient correlation. The value of P<O.05 was significant in statistical analysis.Results Acanthosis nigricans was positive in 33 children. Insulin resistance was found in 34 from 54 subjects, 28 of them has AN and 6has no AN. Obese children with AN had higher HOMA-IR than children without AN. Presence of AN was associated with IR (P<O.OOl, r=0.57).Conclusions There is a weak correlation between AN and IR in obese children. It is important to identify obese children with IR for early intervention and prevention of type 2 diabetes, but AN could not be a reliable marker of IR.
Latar belakang. Angka kejadian diabetes mellitus tipe-2 (DMT2) pada anak di beberapa tahun terakhir inisemakin meningkat seiring dengan meningkatnya angka kejadian obesitas pada anak. Acanthosis nigricans(AN) diyakini merupakan prediktor yang baik untuk mengetahui adanya hiperinsulinemia, yang merupakanprekursor dari DMT2. Penelitian terdahulu menunjukkan prevalensi AN lebih tinggi pada anak-anak yangoverweight, obes, dan mereka yang memiliki riwayat keluarga DMT2.Tujuan. Menilai hubungan AN dengan riwayat keluarga dengan DMT2 pada anak overweight dan obes.Metode. Penelitian cross sectional pada anak sekolah menengah pertama di kecamatan Wenang. Dilakukanpemeriksaan fisik terhadap AN dan pengisian kuesioner berisi riwayat keluarga dengan DM tipe 2 pada102 pelajar yang overweight dan obes. Data kemudian dianalisis menggunakan uji X2.Hasil. Didapatkan AN lebih banyak dijumpai pada anak obes (69,2%) dibandingkan overweight (44%).Riwayat keluarga dengan DM tipe 2 ditemukan pada 30,6% anak obes dengan AN dan 31,8% pada anakdengan overweight. Secara statistik perbedaan kedua prevalens tersebut di atas tidak bermakna.Kesimpulan. Tidak terdapat hubungan yang signifikan antara acanthosis nigricans dengan riwayat keluargadiabetes melitus tipe 2 pada anak-anak overweight dan obes.
Background problem associated with health problems such as metabolic syndrome, diabetes mellitus and cardiovascular disease. A low-grade chronic inflammatory state, reflected by decreased
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