Acute glomerulonephritis (AGN) is characterized by classical clinical triad of sudden onset of edema, hematuria, and hypertension. The clinical picture is unmistakable but laboratory evidences lend additional diagnostic support. This study was aimed to evaluate the clinical profile and complication of children with AGN at Prof. DR. R.D.Kandou Manado Hospital. This was a retrospective study of patients from December 2009 to December 2014. This study was perfomed on 45 patients diagnosed as AGN, aged 1-15 years, admitted at the Pediatric Ward of Prof. Dr. R. D. Kandou Manado Hospital. Data of the clinical and laboratory presentation of these patients were obtained from the medical records. The results showed that the majority of patients (88.8%) were between 5-12 years; only 5 patients below 5 years of age. AGN was twice as common in males as it was in females. It was ushered as acute onset of edema (64.4%), hypertension (46.6%), tea-colored urine (33.3%), and fever (28.8%). The ASTO titre was elevated above 250 Todd units in 68.8% of cases. Of 45 patients, only 18 patients were checked for C3 level and the result showed that all of the 18 patients had C3 <50 mg/dL. The main complications were hypertensive encephalopathy (8.9%) and crisis hyper-tension (4.4%). Conclusion: Clinical profiles of AGN in children in this study are not significantly different from those of other developing countries. Therefore, it will help us a lot in confirming the diagnosis of patients with AGN.Keywords: acute glomerulonephritis, clinical profile, ASTO, complicationAbstrak: Glomerulonefritis akut (GNA) mempunyai karakteristik berupa trias gejala klasik yaitu edema yang terjadi secara tiba-tiba, hematuria, dan hipertensi. Meskipun gambaran klinisnya cukup jelas, tetapi hasil pemeriksaan laboratorium dapat memberikan tambahan untuk mendukung diagnosis. Penelitian ini bertujuan untuk mengevaluasi gambaran klinis dan komplikasi dari GNA yang terjadi pada anak di RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ialah retrospektif pada pasien-pasien dari periode Desember 2009-Desember 2014. Sebanyak 45 pasien yang didiagnosis GNA dengan rentang usia mulai dari 1-15 tahun yang dirawat di bangsal anak rumah sakit Prof. Dr. R. D. Kandou dimasukkan ke dalam penelitian ini. Data mengenai gambaran klinis dan hasil pemeriksaan laboratorium pasien diperoleh dari rekam medik. Hasil peneltiian mendapatkan bahwa sebagian besar pasien (88,8%) berusia 5-12 tahun, hanya 5 pasien dengan usia kurang dari 5 tahun. Anak laki–laki dua kali lebih sering terkena daripada anak perempuan. Penyakit ini ditandai dengan edema yang terjadi secara tiba-tiba (64,4%), hipertensi (46,6%), urin berwarna seperti teh (33,3%), dan demam (28,8%). Peningkatan titer ASTO di atas 250 Todd unit dijumpai pada 68,8% kasus. Dari 45 pasien, hanya 18 pasien yang diperiksakan nilai C3 dan hasilnya memperlihatkan bahwa 18 pasien tersebut memiliki hasil C3 <50 mg/dL. Komplikasi yang sering terjadi ialah hipertensi ensefalopati (8,9%) dan krisis hipertensi (4,4%). Simpulan: Gambaran klinis GNA pada anak di penelitian ini tidak jauh berbeda dengan yang dijumpai di negara berkembang lainnya. Hal ini dapat membantu dalam mendiagnosis pasien dengan glomerulonefritis akut.Kata kunci: glomerulonefritis akut, gambaran klinis, ASTO, komplikasi
Background Acute diarrhea is currently one of the major causes of morbidity and mortality in developing countries. A wide range of enteric pathogens, including bacteria, is responsible for the pathogenesis of acute infectious diarrhea. Recent studies have shown an increase in acute phase proteins, such as serum interleukin-6 (IL-6) levels, in patients with acute bacterial gastroenteritis. Thus, IL-6 may be a useful marker to differentiate bacterial from non-bacterial enteric pathogens.Objective To assess for a correlation between bacterial enteric pathogens and serum IL-6 levels in children with acute diarrhea.Methods We conducted a cross-sectional study from November 2013 to March 2014 in two hospitals in Manado. Subjects were children aged 1-5 years with acute diarrhea and good nutritional status. Subjects’ provided stool samples for bacterial culture and microscopic examination, as well as blood specimens for serum IL-6 measurements. Data was analyzed by linear regression and Pearson’s correlation tests for a correlation between bacterial enteric pathogens and serum IL-6 levels.Results In children with acute diarrhea, those with bacterial enteric pathogens had significantly higher mean serum IL-6 than those with non-bacterial enteric pathogens (r = 0.938; P < 0.001).Conclusion Serum IL-6 levels are significantly more elevated in children with acute diarrhea and bacterial enteric pathogens. Therefore, serum IL-6 may be a useful marker for early identification of bacterial gastroenteritis in children aged 1-5 years. [Paediatr Indones. 2016;56:144-8.].
Nowadays, problems of the quality of the child life is the main priority in national health program, inter alia congenital anomaly which is defined as structural or functional anomaly (example metabolic disorders) that occurs during intrauterine life and can be identified before birth, at birth, or after birth. This study was aimed to find out the risk factors that related to the occurrence of congenital anomalies in the neonati at Prof . Dr. R. D. Kandou Hospital Manado. This was a descriptive retrospective study. Total samples were 66 neonates that fulfilled the inclusion criteria as follows: neonates who were born and taken cared at Prof. Dr. R. D. Kandou Hospital Manado. The results showed that maternal risk factors had a major role to the occurrence of congenital anomalies. Conclusion: Maternal infection during pregnancy was the most common risk factor, however, several congenital anomalies had unknown risk factor.Keywords: neonates, congenital anomalies, maternal risk factor Abstrak: Pada zaman sekarang ini masalah kualitas hidup anak merupakan prioritas utama bagi program kesehatan nasional. Salah satu faktor yang memengaruhi kualitas hidup anak ialah adanya kelainan bawaan yaitu anomali struktural atau fungsional (misalnya gangguan metabolisme) yang terjadi selama hidup intrauterin dan dapat diidentifikasi sebelum lahir, saat lahir, atau di kemudian hari. Penelitian ini bertujuan untuk mengetahui faktor risiko yang berhubungan dengan kejadian kelainan bawaan pada neonatus di RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ialah deskriptif retrospektif. Sampel sebanyak 66 neonati dengan kriteria inklusi neonatus yang lahir dan dirawat di RSUP Prof Dr. R. D. Kandou Manado. Hasil penelitian memperlihatkan bahwa faktor risiko ibu berperan penting terhadap kejadian kelainan bawaan. Simpulan: Infeksi ibu selama kehamilan merupakan faktor risiko ibu yang paling sering ditemukan pada kelainan bawaan. Walalupun demikian, terdapat juga faktor-faktor yang tidak diketahui yang memengaruhi kejadian kelainan bawaan. Kata kunci: neonatus, kelainan bawaan, faktor risiko ibu
Obesity is now a global problem. The prevalence is increasing not only in developed countries but also in developing countries. Currently, obesity in children is still a complex issue. The cause is multifactorial, making it hard for the implementation. The increasing of overweight and obesity in children around the world participate to boost the prevalence of hypertension in children. Observing the heredity aspect of hypertension, emerging understanding that hypertension in adults are from children. Therefore, efforts to reduce the prevalence of overweight and obesity will decrease the prevalence of hypertension in children indirectly. Objective: To determine the relationship of obesity with blood pressure in children aged 10-12 years. Methodology: This study was observational analytic cross sectional design. Results: There were 111 children as the subjects of study that meets the inclusion criteria which have been measured. Consisted of 57 girls and 54 boys. Of 111 obese children are 31 children with normal blood pressure, 55 children with high-normal blood pressure and 25 children with high blood pressure, there is a significant relationship with the Chi-Square Test (p = 0.007). Conclusion: There is a relationship between obesity and blood pressure appearance in children aged 10-12 years. Keywords: blood Pressure, hypertension, obesity. Abstrak: Obesitas saat ini sudah menjadi masalah global. Prevalensinya meningkat tidak saja dinegara maju tapi juga di negara-negara berkembang. Obesitas pada anak sampai saat ini masih merupakan masalah yang kompleks. Penyebabnya multifaktorial sehingga menyulitkan penatalaksanaannya. Peningkatan kegemukan dan obesitas pada anak di seluruh dunia ikut mendongkrak prevalensi hipertensi pada anak. Melihat unsur keturunan dari hipertensi, muncul pemahaman bahwa hipertensi pada orang dewasa berasal dari anak-anak. Oleh karena itu upaya menurunkan prevalensi kegemukan dan obesitas akan menurunkan prevalensi hipertensi pada anak secara tidak langsung. Tujuan: Untuk mengetahui hubungan obesitas dengan tekanan darah pada anak usia 10-12 tahun. Metode: Penelitian ini merupakan penelitian observasional analitik dengan rancangan potong lintang. Hasil: Terdapat 111 anak subjek penelitian yang memenuhi kriteria Inklusi yang telah diukur. Terdiri dari 57 anak perempuan dan 54 anak laki-laki. Dari 111 anak obes tersebut 31 anak dengan tekanan darah normal, 55 anak dengan tekanan darah normal tinggi dan 25 anak bertekanan darah tinggi, terdapat hubungan bermakna dengan Uji Chi-Square (p=0,007). Simpulan: Terdapat hubungan antara obesitas dan profil tekanan darah pada anak usia 10 – 12 tahun. Kata Kunci: Hipertensi, Obesitas, Tekanan Darah
Background Urinary tract infections (UTI) may affect any part
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