The risk of urinary tract infection in children with nephrotic syndrome

Gunawan, Patricia Yulita; Umboh, Adrian

doi:10.14238/pi56.4.2016.238-41

Cited by 6 publications

(6 citation statements)

References 3 publications

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“…Similar antibiotic susceptibility was found in the study by Sreenivasa et al Where majority of the organisms were found to be sensitive to 3 rd generation Cephalosporins and Aminoglycosides [5]. In the study by Patricia Y.Gunawan and Adrian Umboh E. coli was one of the common organisms and Imipenem and Amikacin were found to be most common sensitive antibiotics [8].…”

Section: Discussionsupporting

confidence: 78%

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Incidence of Urinary Tract Infection, Identification of Pathogen and Drug Sensitivity Pattern in Children with Nephrotic Syndrome

Mondal¹,

Mohapatra²,

Roy³

et al. 2019

SJMPS

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Introduction: Nephrotic syndrome is primarily a pediatric disorder and it affects 1-3 per 100,000 children <16 years of age. The prevalence of UTI is high in nephrotic syndrome patients.UTI may be responsible for poor response to steroid therapy and it also induces relapses. Objectives: To determine the incidence of urinary tract infection, identifications of pathogen and antibiotic sensitivity pattern of UTI in children with nephrotic syndrome. Method: All nephrotic syndrome patients attending the OPD or Indoor who are fulfilling the criteria were included in the study. Detailed history was taken. Routine tests including the urine culture sensitivity were sent. Result: Incidence of UTI among nephrotic syndrome patients was18.75%. E.coli, Enterococcus, Klebsiella sp., Acinetobacter was the organisms. Commonest organism found was E.coli. Aminoglycoside group of drugs found to be the most sensitive (100%) followed by third generation cephalosporin (80%). Conclusion: UTI is not at all uncommon in nephrotic syndrome patients and all the patients may not present with classical symptoms. Hence a high degree of suspicion is essential for early diagnosis.

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Section: Discussionsupporting

confidence: 78%

“…Steroid and other immunosuppressive therapies also increase the risk [7]. In our study the incidence of UTI in NS was found to be 18.75% whereas in the study by Patricia Y and others it was 46% [8]. In another study from South India the incidence was found to be 40% which are quite high than our study [5].…”

Section: Discussioncontrasting

confidence: 60%

Incidence of Urinary Tract Infection, Identification of Pathogen and Drug Sensitivity Pattern in Children with Nephrotic Syndrome

Mondal¹,

Mohapatra²,

Roy³

et al. 2019

SJMPS

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“…[ 9 ] A many studies state that NS is more common in boys (64.9%) and UTI is more common in girls but NS with UTI is more common in girls (67.6%). [ 12 13 14 15 ] In our study, the most common age for NS also found to be 2-6 years and gender predominance to be Male with M: F = 2.3:1. Among positive cultures, female predominated with the M: F = 0.6:1.…”

Section: Discussionsupporting

confidence: 52%

“…show E. coli as the predominant culture growth. [ 2 11 12 18 22 ] However, Adeleke et al . found Staphyloccous aureus (61.2%), followed by Klebsiella.…”

Section: Discussionmentioning

confidence: 99%

Urinary tract infection in children with Nephrotic syndrome: One of the hurdles for primary care physician and pediatrician towards timely diagnosis and optimum management of the disease

Mohan

Indurkar²,

Omar³

et al. 2022

Journal of Family Medicine and Primary Care

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A BSTRACT Background: Urinary tract infection (UTI) is a common infection in children with nephrotic syndrome (NS). Clinical experience suggests that childhood nephrotic syndrome is frequently diagnosed incorrectly and managed inadequately on the top of this existing UTI in the episode becomes an additive obstacle for the primary care physicians or pediatricians towards optimum management, leading to poor outcome. So, we have conducted this clinico- microbiological study of UTI in NS in children to provide the exact picture of UTI with NS so that the primary care providers can be helped in having high index of suspicion of this infection and knowing prevalent organisms and their antimicrobial sensitivity pattern. Aim: The aim of the study was to study clinical features and identify the responsible organisms with its drug sensitivity pattern with response to treatment in various types and stages of NS with UTI in children. Methods: This cross-sectional hospital based study was conducted on 50 children of 2-18 years of age with NS attending nephrology clinic or admitted to the Paediatric ward of AIIMS, Rishikesh. Demographic, clinical, and microbiological data were recorded and details were entered in a predesigned proforma sheet. Results: Out of 50 cases, 8 (16%) had a positive urine culture. Six (75%) out of them had first episode and two (25%) were frequent relapsers of NS. Fever, decreased urine output, and generalized edema were the presenting features. The most common bacteria responsible for UTI was Pseudomonas aeruginosa (in around 25% isolates). Escherichia coli and Citrobacter koseri were the most resistant organisms. Patients were treated with antibiotics according to sensitivity pattern which resulted in resolution of symptoms and repeat urine culture became sterile subsequently. Conclusion: About one-sixth of children with Nephrotic Syndrome had UTI. UTI should be ruled out in every case of NS in active phase to prevent long-term morbidity and mortality.

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“…At present, the incidence of PNS combined with UTI is increasing year by year, and has become the primary problem in the prevention and control of infectious diseases all over the world (29,30). Due to tissue edema, loss of immunoglobulins, and the use of immunosuppressants, the defense system of children with PNS is damaged, leading to low immunity and infection, which may even be life-threatening (31). In this paper, the risk factors of PNS with UTI were studied by meta-analysis.…”

Section: Discussionmentioning

confidence: 99%

The risk factors for children with primary nephrotic syndrome: a systematic review and meta-analysis

Zheng¹,

Chen²,

Jing³

et al. 2021

Transl Pediatr

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The risk of urinary tract infection in children with nephrotic syndrome

Abstract: Background Urinary tract infections (UTI) may affect any part

Cited by 6 publications

References 3 publications

Incidence of Urinary Tract Infection, Identification of Pathogen and Drug Sensitivity Pattern in Children with Nephrotic Syndrome

Incidence of Urinary Tract Infection, Identification of Pathogen and Drug Sensitivity Pattern in Children with Nephrotic Syndrome

Urinary tract infection in children with Nephrotic syndrome: One of the hurdles for primary care physician and pediatrician towards timely diagnosis and optimum management of the disease

The risk factors for children with primary nephrotic syndrome: a systematic review and meta-analysis

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