In this paper we experimentally demonstrate the fabrication and operation of a
rapidly prototyped optical cylindrical micro-waveguide based biosensor. This device
works on the principle of variation to the light intensity and path of coupled
input light due to the binding of protein bio-molecules onto the micro-waveguide
surface as a method of physical transduction. The variation to the coupled light
intensity and path is dependent on the nature of the bio-molecule and the
density of the bio-molecules. This technique has been used to identify protein
biomarkers for inflammation and thrombosis, namely myeloperoxidase (MPO) and
C-reactive protein (CRP). The detection limit that has been demonstrated is
pg ml−1. The detection speed is of the order of seconds from the time of injection of the
bio-molecule. The optical signature that is obtained to identify a protein bio-molecule is
entirely dependent on the nature of adsorption of the bio-molecule on to the
cylindrical cavity surfaces. This in turn is dependent on the protein conformation and
the surface charge of the bio-molecules. Hence a specific protein bio-molecule
generates a unique optical identifier based on the nature of binding/adsorption to
the cavity surface. This physical phenomenon is exploited to identify individual
proteins. This technique is a demonstration of detection of nano-scale protein
bio-molecules using the optical biosensor technique with unprecedented sensitivity.
In this paper, Barlase has been taken a step further by emulating the degradation processes in high power semiconductor laser bars using an upgraded version of Barlase by the introduction of a global thermal solver to further deepen the understanding of the behaviour of laser bars. In this paper, the emulation of a real laser bar was investigated to emulate experimental results by simulating the experimental results in the view of finding a correlation between them. The results established show a more elaborate frown shaped power/current profile and a corresponding frown shaped temperature profile especially at the front facet of the laser bar. Even though a more elaborate frown shaped profile was realised in the power, current and temperature profiles, it fell short from what was seen in the experimental results. As the emulation of laser bar degradation has not been attempted before, further work is needed to achieve better agreement in the output power, current and temperature profiles to better the model.
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