We have considered short-baseline neutrino oscillations, 3 H β-decay and (ββ) 0ν -decay in two schemes with an inverted mass spectrum and mixing of three and four massive neutrino fields. We have analyzed the results of the latest experiments on the search for oscillations of terrestrial neutrinos and we have discussed the compatibility of the LSND indication in favor of neutrino oscillations with the results of the other experiments. In the framework of the models under consideration, it is shown that the observation of (ββ) 0ν -decay 1 could allow to obtain information about the CP violation in the lepton sector.

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Three different clinical courses were found in six patients with an HV-like eruption associated with chronic EBV infection: (i) spontaneous remission; (ii) clearing after photoprotection; and (iii) continuous recurrence irrespective of sun exposure. It is possible that there are two patterns of HV-like eruption associated with chronic EBV infection. One is characterized by recurrent necrotic papulovesicles of the face and the other by nodules and facial swelling. It was demonstrated that the skin lesions could be triggered by repeated UVA exposure in the patients showing recurrent necrotic papulovesicles of the face.

Cell migration and angiogenesis are key steps in tumor metastasis. However, the mechanism of migration regulated by vascular endothelial growth factor (VEGF), a potent regulator of angiogenesis, is not completely understood. This study examined the relationship between VEGF and migration, along with the mechanism involved in the VEGF-regulated migration of human gastric cancer cells. The level of cell migration was increased by recombinant human (rh)VEGF-165 in the VEGF receptor-2-expressing SNU-601 cells. Interleukin (IL)-18 is associated with the malignant progression of tumors. Accordingly, this study examined the effect of IL-18 on the migration of cancer cells in order to identify the factors involved in VEGF-enhanced migration. Inhibiting IL-18 markedly reduced the level of VEGF-enhanced migration, and IL-18 increased cell migration directly through filamentous-actin polymerization and tensin downregulation. It was confirmed that rhVEGF-165 increased IL-18 production significantly. An antioxidant and an extracellular signal-regulated kinase (ERK)1/2-specific inhibitor blocked rhVEGF-165-enhanced IL-18 production. Accordingly, rhVEGF-165 increased the generation of region of interest (ROI) and activated the ERK1/2 pathway. These results suggest that rhVEGF-165 enhances IL-18 production via the generation of ROI and ERK1/2 phosphorylation, which results in the increased migration of gastric cancer cells.

Objectives: Given that obsessive-compulsive disorder (OCD) and schizophrenia may share clinical symptoms as well as functional brain abnormalities, this study was designed to clarify common and different morphological abnormalities in OCD and schizophrenia. Methods: Volumes of the hippocampus, the amygdala, and the thalamus were measured in three age and sex matched groups of 22 patients with OCD, 22 patients with schizophrenia, and 22 normal subjects using three dimensional magnetic resonance imaging. Volume tracing was performed manually on serial coronal slices with the references of sagittal or axial planes using internal landmarks. Results: Hippocampal volume was bilaterally reduced in both OCD and schizophrenic patients versus the normal controls. Left amygdala volume was significantly enlarged in patients with OCD but not in patients with schizophrenia versus the normal controls. The thalamus did not show any volumetric group differences. Conclusions: Non-specific hippocampal reduction in both the OCD and schizophrenic groups is likely to link to a clinical overlap between the two illnesses, whereas the left amygdala enlargement observed only in the OCD patients seems to be suggestive of a unique role for the amygdala in the pathophysiology of OCD.A lthough OCD and schizophrenia are separate psychiatric disorders, patients having comorbidities of the two illnesses are frequently found in clinical practice. Based on functional and structural neuroimaging findings, the possible overlap has been also identified in the pathophysiology of the two illnesses, in particular abnormalities in the frontostriatal circuits.1 Other candidate structures for such overlapping pathophysiology may include the thalamus and/or the hippocampus-amygdala complex. It is noteworthy that although similar regions have been identified to be functionally or morphologically abnormal in both illnesses, they tend to occur in opposite directions: for example, hyperfunctional fronto-striatal systems in OCD, 2 but hypofunctional in schizophrenia 3 ; and thalamic enlargement in OCD, 4 but thalamic reduction in schizophrenia. 5Based on such significant but different findings of similar regions in OCD and schizophrenia, we hypothesised that the two illnesses would also show quite different abnormal patterns in the hippocampus-amygdala complex. Moreover, it was expected that such morphological changes, if identified, would correspond to hyperfunctional circuitry in OCD, but hypofunctional circuitry in schizophrenia. To test this hypothesis, volumes of the hippocampus, the amygdala, and the thalamus were compared in patients with OCD, in patients with schizophrenia, and in normal subjects. METHODS SubjectsThere were three age and sex matched groups: OCD, schizophrenia, and normal subjects. Each group consisted of 22 subjects (15 men and 7 women), who were all right handed, and had a mean age of 26.7 (SD 7.2), 26.6 (SD 6.5), and 26.2 (SD 6.1) years, respectively. Patients were recruited from Seoul National University Hospital, and none had a dual...

We conclude that lineage assignment (T vs. B) in the REAL classification is a clinically important distinction, but that it is necessary to subdivide the broad category of DLBCL.

We conclude that isoallergens of Der p 2 may have different IgE immune responses. Quantification of Der p 2 with 2-site ELISA kits that adopted mAbs, might be affected by the prevalent form of the isoallergens in reservoir dust.

Although the hyper-glycosylated transmembrane protein Mucin 1 (MUC1) is aberrantly overexpressed in human breast carcinoma, the biological significance of MUC1 overexpression is unclear. This study showed that MUC1 expression promoted the synthesis and secretion of vascular endothelial growth factor (VEGF) through the AKT signaling pathway. Increase VEGF production through MUC1 expression had a number of effect. First, MUC1 transfection increased expression of VEGF in breast cancer cells. Second, MUC1-mediated VEGF induction was attenuated by a chemical inhibitor of AKT or MUC1 knock-down by MUC1 siRNA. Third, MUC1 expression led to the activation of insulin-like growth factor-1 receptor, which correlated with VEGF expression. In addition, when MDA-MB-231 human breast cancer cells were directly injected into NOD/SCID mice, MUC1 expression accelerated xenograft tumor growth in vivo. Finally, MUC1 expression enhanced tumor growth and angiogenesis in a PyMT-MMTV/ hMUC1 transgenic mouse model. Concurrent with these results, analysis of a human tissue microarray identified a high correlation between MUC1 and VEGF expression in human breast carcinoma. The current report is the first to demonstrate that MUC1 expression promotes angiogenesis in human breast cancer in vivo and in vitro.