“…One of the brain structures which has been a focus of research is the hippocampal formation. Magnetic resonance (MR)-based in vivo measurement of hippocampal volume is an accepted technique, which has been performed in the aged 1 and healthy subjects, 2 and has revealed a number of structural abnormalities in a variety of neurological and psychiatric disorders, such as temporal lobe epilepsy, 3 Huntington's disease, 4 Turner's syndrome, 5 Cushing's disease, 6 Down's syndrome, 7 Alzheimer's disease (AD), 8 mild cognitive impairment, 9 schizophrenia, 10 major depression (MD), 11 bipolar disorder, 12 post-traumatic stress disorder (PTSD), 13 borderline personality disorder, 14 chronic alcoholism, 15 obsessive-compulsive disorder, 16 and panic disorder. 17 The MR-derived hippocampal volumetric technique has demonstrated good validity and reproducibility, [18][19][20] and accuracy of the measurements has been shown by MRI volumetric measurement of phantoms with a known volume.…”