Human peripheral lymphocytes were stimulated to incorporate tritiated thymidine when cultured with anti-δ. The stimulation of lymphocytes by anti-δ inversely correlates to PHA-induced lymphocyte transformation. In addition, lymphocytes from individuals with low serum IgD levels exhibited a significant response to anti-δ, whereas, those with normal or slightly elevated levels of serum IgD showed minimal stimulation. This study is the first to provide evidence that cell surface IgD may regulate metabolic functions of lymphocytes and is consistent with the idea that IgD is a ‘triggering’ receptor.
The relative frequency of peripheral blood T and B cells and their biological function(s) from a group of patients with pityriasis rosea (PR) was investigated during the acute and convalescent phases of the disease using rosetting, immunofluorescent tests, and in vitro cell culturing with anti-δ and anti-μ antibodies and phytohemagglutinin (PHA). The total number of immunoglobulin (Ig) bearing cells was significantly increased, in conjunction with a slight decrease in the T cell population. Lymphocytes with surface IgD, IgM, or both Ig, accounted for the increase in the B cell population. This increase was transient, since it was only observed during the acute phase of the disease. In spite of the increase in IgD/IgM bearing B cells, the mitogenic responsiveness of B or T lymphocytes to anti-δ, anti-μ, or PHA was similar to the same patients during the convalescent phase, or to normal donors. Similary, the levels of serum IgM, IgD, IgG, IgA and IgE in PR remained constant and at a normal concentration throughout the experimental period. The significance of the transient increase in IgD/IgM bearing cells in the pathogenesis and etiology of PR and its possible impact on the immune system is discussed.
The effects of passive immunization with immunoglobulin Y (IgY) on the pathogenesis of Marek's disease (MD) were examined in an experimental line of White Leghorn chickens highly susceptible to MD. Purified IgY with anti-MDV antibody activity, when injected into chicks, delayed the development of MDV viremia and lesions until 9 days postinoculation (PI) with Marek's disease virus (MDV). The blastogenic response of spleen cells to concanavallin-A was depressed at 6 days PI in the birds without passive immunization, whereas it was not totally depressed until 17 days in birds passively immunized with IgY anti-MDV antibody.
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