Structure and Biological Function of Human IgD

Kermani-Arab,; Ga, Leslie; Dr, Burger

doi:10.1159/000231802

Cited by 7 publications

(1 citation statement)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Suppressor cells for antibody production can be induced in agammaglobulinemic (Ay) chickens by injection of B cells [l] and transfer of agammaglobulinemia to irradiated normal recipients is readily obtained with such suppressor cells [2][3][4]. However, induction of antigen-specific suppressor cells in chickens appears facilitated by the presence of bursa-"dependent" thymus cells, since suppressor activity is more significant with thymus cells from normal than from bursectomized chickens [S].…”

Section: Introductionmentioning

confidence: 99%

Antigen‐induced helper and suppressor T cells in normal and agammaglobulinemic chickens

1980

View full text Add to dashboard Cite

Spleen cells from chickens injected with sheep erythrocytes (SE) intravenously 2 to 14 days prior to culture were found to give faster and higher plaque-forming cell responses upon addition of antigen on day 2 rather than on day 0 of culture. Cell mixture experiments showed that this was due to the induction of suppressor T cells upon re-exposure to SE on day 0 of culture. Spleen cells taken on days 2 or 14, but not between days 4 and 7 after priming to SE were sensitive to suppression. The suppressor cells were resistant to gamma irradiation (1000 rd) and to mitomycin C, but were apparently lost after 2 days of culture in the absence of antigen. Pokeweed mitogen addition on day 0 of culture also induced suppressor cells, both in SE immune and in normal spleen. Similar suppressor cells were induced in cultures of primed spleen cells taken from agammaglobulinemic chickens. The response to Brucella abortus in vitro was not affected by induction of suppression for the anti-SE response. Suppression could also be shown after transfer of cell mixtures to irradiated recipients. Helper cell activity for the anti-SE response could readily be shown, both in vivo and in vitro, in primed spleen cells precultured for 2 days in the absence of antigen, and was also resistant to 1000 rd gamma irradiation and to mitomycin C.

show abstract

Section: Introductionmentioning

confidence: 99%