Effects of IgY Antibody on the Development of Marek's Disease

Abstract

The effects of passive immunization with immunoglobulin Y (IgY) on the pathogenesis of Marek's disease (MD) were examined in an experimental line of White Leghorn chickens highly susceptible to MD. Purified IgY with anti-MDV antibody activity, when injected into chicks, delayed the development of MDV viremia and lesions until 9 days postinoculation (PI) with Marek's disease virus (MDV). The blastogenic response of spleen cells to concanavallin-A was depressed at 6 days PI in the birds without passive immunization, whereas it was not totally depressed until 17 days in birds passively immunized with IgY anti-MDV antibody.

Production of IgY Specific Antibody Against Entero Pathogenic Escherichia coli (EPEC) in Egg Yolk

“…Sampai saat ini, pemanfaatan lgY spesifik dalam telur ayam untuk pengobatan dan pencegahan penyakit masih terbatas pada skala laboratorium. Pada hewan, pemanfaatan lgY pernah dilaporkan oleh Kermani-Araeb et al (2001), yang menyatakan bahwa lgY spesifik terhadap penyakit Marek yang diaplikasi secara pasif mampu menahan infeksi virus Marek. Dilaporkan pula bahwa penyakit colibacilosis dan influenza pada unggas dapat dicegah dengan pemberian lgY spesifik secara pasif.…”