Wedescribe a case of recurrent histiocytic necrotizing lymphadenitis (HNL) with aseptic meningitis. The patient was a 46-year-old male and a carrier of humanT lymphotropic virus type I (HTLV-I). The patient had a past medical history of at least three relapses of HNL. In addition, his sister, whowas also an HTLV-Icarrier, had recurrent clinical episodes consistent with those ofHNL, suggesting familial HNLoccurrence. This observation suggests the possibility that HTLV-I infection is relevant to the pathogenesis of HNL. (Internal Medicine 35: 821-825, 1996)
Adamantinomais a rare bone tumor, most of which originates in the long bone. Here, we present a case of adamantinomaof the rib with liver metastasis. The patient, a 69-year-old man, complained of dull chest pain for over 6 months. Chest X-ray and CTfilm revealed osteolytic mass of the right 7th rib. Under the clinical diagnosis of hepatic tumor with rib metastasis, resection of the rib and partial hepatectomy were performed. Pathologically, the bone tumor was diagnosed as primary adamantinomaand the liver tumor was its metastasis. The patient has been well without adjuvant chemotherapy for 5 years after the operation. (Internal Medicine 33: 441-445, 1994)
We report five cases of hypersensitivity pneumonitis among workers cultivating Tricholoma conglobatum (shimeji). After having worked for 5 to 20 years, they began to notice symptoms of cough, sputum, and dyspnea. They were diagnosed as having a hypersensitivity pneumonitis based on clinical features, bronchoalveolar lavage and transbronchial lung biopsy. By the double immunodiffusion test, precipitating lines between shimeji spore antigen and sera were observed in all of the patients. By enzyme-linked immunosorbent assay, the antibody activities against shimeji and three species of fungi (Cladosporium sphaerospermum, Penicillium frequentans, and Scopulariopsis species) were significantly higher in the sera of the patients than in those of normal subjects who were cultivating shimeji. Although it is not clear what causes this disease, these findings may be helpful in determining the specific antigen.
ABSTRACT-Background.Cases of lung cancer with bone formation in the cancer lesion are rare. We report a case of adenocarcinoma with stromal ossification. Case. In a 66-year-old man undergoing x-ray examination of the stomach showed an abnormal nodular lesion was found in the right basal area of the lung. Chest high resolution computed tomography revealed a nodular lesion with pleural indentation and a minute high-density area resembling calcification. He underwent a resection of the right lower lobe of the lung with hilar and mediastinal lymphnode dissection.
Conclusion.Postoperative pathological examination revealed that there was an ossification island in the center of stroma of the nest of the adenocarcinoma. An immunohistochemical examination revealed that cancer cells around the ossification island showed moderate expression of Bone morphogenetic protein 2. (JJLC. 2002; 42: 51-54) KEY WORDS-Lung cancer, Adenocarcinoma, Heterotopic ossification, Bone morphogenetic protein 2, Bone morphogenetic protein 4
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