Lung Adenocarcinoma With Stromal Ossification.

Abstract

ABSTRACT-Background.Cases of lung cancer with bone formation in the cancer lesion are rare. We report a case of adenocarcinoma with stromal ossification. Case. In a 66-year-old man undergoing x-ray examination of the stomach showed an abnormal nodular lesion was found in the right basal area of the lung. Chest high resolution computed tomography revealed a nodular lesion with pleural indentation and a minute high-density area resembling calcification. He underwent a resection of the right lower lobe of the lung with hilar and mediastinal lymphnode dissection. Conclusion.Postoperative pathological examination revealed that there was an ossification island in the center of stroma of the nest of the adenocarcinoma. An immunohistochemical examination revealed that cancer cells around the ossification island showed moderate expression of Bone morphogenetic protein 2. (JJLC. 2002; 42: 51-54) KEY WORDS-Lung cancer, Adenocarcinoma, Heterotopic ossification, Bone morphogenetic protein 2, Bone morphogenetic protein 4

Clinicopathological analysis of primary lung carcinoma with heterotopic ossification

“…In EHO, 4 of 17 (23.5%) cases were positive for BMP-2, which was originally described as a protein that can induce ectopic bone formation [24]. Immunohistochemical studies utilizing anti-BMP-2 antibody for heterotopic ossification associated with neoplasms have been reported [5,12,19,22], including two cases of primary lung carcinoma [19,22]. These results indicate that one of the bone-forming factors was BMP-2.…”

“…Bone morphogenetic protein-2 (BMP-2), which is a subtype of the BMP family and a member of the transforming growth factor-␤ (TGF-␤) superfamily, was originally described as protein that can induce ectopic bone formation when implanted into muscle tissue in vivo [24]. In primary lung carcinoma, Hosoda et al [19] and Usami et al [22] reported cases that showed the expression of BMP-2 within tumor cells having heterotopic intratumoral ossification.…”

“…The presence of pulmonary ossification associated with lung tumors was mainly reported in carcinoid [13] and metastatic lung tumors [14]. Heterotopic ossification in primary lung carcinoma is extremely rare, and has been reported in only nine cases [15][16][17][18][19][20][21][22][23].…”