Clinicopathological analysis of primary lung carcinoma with heterotopic ossification

Kuribayashi, Hideki; Tsuta, Koji; Mizutani, Eiki; Maeshima, Akiko Miyagi; Yoshida, Yukihiro; Gemma, Akihiko; Kudoh, Shoji; Asamura, Hisao; Matsuno, Yoshihiro

doi:10.1016/j.lungcan.2008.08.007

Cited by 10 publications

(13 citation statements)

References 23 publications

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“…8 Immunohistochemical studies using anti-BMP-2 antibody have shown heterotopic ossification to be associated with neoplasms in the lung. 32 IHO is seen more frequently in papillary thyroid carcinoma than in other organ carcinomas. Thus, BMP-2 expression in carcinoma cells was considered to be important for the IHO.…”

Section: Papmentioning

confidence: 93%

Papillary Thyroid Carcinoma With Heterotopic Ossification Is a Special Subtype With Extensive Progression

Takeda

Mikami

Numata

et al. 2013

American Journal of Clinical Pathology

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An immunohistochemical study was conducted of 108 papillary carcinoma cases, including 48 cases with intratumoral heterotopic ossification (IHO). In 48 cases, papillary carcinoma with IHO was accompanied by nodular fibrosis. Cases of papillary carcinoma with IHO or nodular fibrosis showed higher incidences of lymph node metastasis, multifocal lesions, and extrathyroidal invasion than those without IHO and nodular fibrosis. A higher number of stromal myofibroblasts was observed in papillary carcinoma with IHO or nodular fibrosis than in that without fibrosis. Expression of both basic fibroblast growth factor (bFGF) and bone morphogenetic protein (BMP)-2 was the highest in papillary carcinoma with IHO. Papillary carcinoma with IHO showed higher vascular invasion and higher numbers of capillaries expressing nestin, which is associated with high expression of vascular endothelial growth factor (VEGF). Papillary carcinoma with IHO is a unique subtype with extensive progression including frequent lymph node metastasis, multifocality, and invasive behavior. Papillary carcinoma with IHO was correlated with expression of bFGF, BMP-2, and VEGF in the carcinoma cells, leading to neovascularization.

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Section: Papmentioning

confidence: 93%

Papillary Thyroid Carcinoma With Heterotopic Ossification Is a Special Subtype With Extensive Progression

Takeda

Mikami

Numata

et al. 2013

American Journal of Clinical Pathology

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“…Several local factors are known to promote the metaplasia of fibroblasts into bone tissues, including BMPs and other transforming growth factor β proteins, as well as fibroblast growth factor . BMP‐2 can induce osteoblastic differentiation from pluripotent cells, and its expression in tumor cells with ossification or calcification has been reported in several tumors . Additionally, tumors with ossification showed BMP‐2 expression while those without ossification showed low or negative BMP‐2 expression in renal cell carcinoma, rectal adenocarcinoma, and thyroid papillary carcinoma .…”

Section: Discussionmentioning

confidence: 99%

“…The mechanism underlying intratumoral ossification is not well understood; however, it may involve bone morphogenetic proteins (BMPs), which are members of the transforming growth factor‐β superfamily . BMP‐2 has been shown to induce osteoblastic differentiation from pluripotent cells, and its expression has been reported in several types of tumors with intratumoral ossification . BMP‐2 is therefore considered a possible mediator of this process.…”

mentioning

confidence: 99%

Bone morphogenetic protein‐2 expression in an intraductal papillary mucinous neoplasm with marked ossification: A case report

Hadano

Hirabayashi

Yamamuro

et al. 2016

Pathology International

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Intratumoral ossification has been reported in a number of epithelial tumors, but its presence in intraductal papillary mucinous neoplasms (IPMNs) is very rare. Herein, we present a rare case of IPMN with marked ossification. A 56-year-old Japanese man was under follow-up for a previously diagnosed IPMN. Seven years later, he was found to have dilatation of the main pancreatic duct and an enlarged solid mass, for which pancreaticoduodenectomy was performed. Macroscopically, multiple and cystically dilated pancreatic branch ducts, as well as a dilated main pancreatic duct, were identified. There was a solid, polypoid hard mass measuring 15 × 12 mm in the cystically dilated branch of the duct in the pancreatic head. Histological examination revealed papillary proliferation of atypical cuboidal or columnar epithelial cells in the dilated main and branch pancreatic ducts. The solid mass included an invasive adenocarcinoma component with a tubular or trabecular structure that showed pronounced ossification. We diagnosed the patient with invasive IPMN accompanied by marked ossification. Immunohistochemically, tumor cells in both the non-invasive and invasive lesions expressed bone morphogenetic protein-2 (BMP-2). While the mechanism of intratumoral ossification is unclear, it may have involved BMP-2 in the present case.

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“…Heterotopic ossification of primary pulmonary adenocarcinoma has been postulated to occur via intramembranous bone formation induced by the tumor cells (3). In an extensive review of 2269 surgically resected primary lung carcinomas by Shoji, 33 cases with heterotopic ossification, including 15 cases with intratumoral heterotopic ossification (IHO) and 18 cases with extratumoral heterotopic ossification (EHO) were identified (7). all cases with IHO were adenocarcinomas and 10 of 15 (66.6%) cases had confirmed positive mucin staining in the tumor cells.…”

Section: Discussionmentioning

confidence: 99%

Squamous cell carcinoma of lung with osteo-cartilaginous metaplasia – a case report and review of the literature

Makhdoomi¹,

Baba²,

Malik³

et al. 2013

TJPATH

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Calcification and ossification are very rare in primary squamous cell carcinoma of the lung. We report a 55-year-old male with primary squamous cell carcinoma of the lung who on histopathological examination was seen to have extensive calcification and ossification. Squamous carcinoma of the lung rarely presents with osteocartilaginous metaplasia. The case is presented here for its unique presentation.

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Clinicopathological analysis of primary lung carcinoma with heterotopic ossification

Cited by 10 publications

References 23 publications

Papillary Thyroid Carcinoma With Heterotopic Ossification Is a Special Subtype With Extensive Progression

Papillary Thyroid Carcinoma With Heterotopic Ossification Is a Special Subtype With Extensive Progression

Bone morphogenetic protein‐2 expression in an intraductal papillary mucinous neoplasm with marked ossification: A case report

Squamous cell carcinoma of lung with osteo-cartilaginous metaplasia – a case report and review of the literature

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Clinicopathological analysis of primary lung carcinoma with heterotopic ossification

Cited by 10 publications

References 23 publications

Papillary Thyroid Carcinoma With Heterotopic Ossification Is a Special Subtype With Extensive Progression

Papillary Thyroid Carcinoma With Heterotopic Ossification Is a Special Subtype With Extensive Progression

Bone morphogenetic protein‐2 expression in an intraductal papillary mucinous neoplasm with marked ossification: A case report

Squamous cell carcinoma of lung with osteo-cartilaginous metaplasia &#8211; a case report and review of the literature

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Squamous cell carcinoma of lung with osteo-cartilaginous metaplasia – a case report and review of the literature