Adamantinoma of the Rib Metastasizing to the Liver.

Beppu, Hozumi; Yamaguchi, Hiroshi; Yoshimura, Nobuyuki; Atarashi, Kenichi; Tsukimoto, K.; Nagashima, Yoji

doi:10.2169/internalmedicine.33.441

Cited by 18 publications

(9 citation statements)

References 5 publications

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“…This tumor is almost exclusively found in the tibia. Rare examples of metastatic ameloblastoma and adamantinoma have been reported in the liver [2,3]. However, no bone lesions were identified in our patient during her follow-up PET-CT.…”

Section: Discussionmentioning

confidence: 45%

“…Some examples include variants of squamous cell carcinoma such as basaloid squamous carcinoma, which shows prominent palisading of basaloid cells and brisk mitotic activity [1]. Several case reports and small series have shown tumors with similar morphology but of low-grade cytology including metastatic ameloblastoma and adamantinoma [2,3]. However, liver metastasis of well-differentiated ameloblastoma generally occurs years after diagnosis of the primary and often follows multiple local recurrences [3].…”

Section: Introductionmentioning

confidence: 99%

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Multifocal Large Cystic Liver Metastasis of a Sinonasal Tract Ameloblastoma: An Unusual Clinical Presentation

Liu

2013

J Med Cases

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Ameloblastoma is a slowly growing, locally invasive tumor of odontogenic epithelial origin. On rare occasion, a well-differentiated ameloblastoma may metastasize. Recently, we encountered a unique case of metastatic ameloblastoma in the liver in a 48-yearold woman. Preoperative radiographic study revealed multiple cystic lesions in the liver, 6 of which were confirmed intraoperatively. Macroscopic examination of the resected tumors revealed well-circumscribed, encapsulated cystic lesions. Sections from the tumors demonstrated solid interlocking islands with peripheral palisading of "basaloid cells" and squamous differentiation of centrally located cells. The cytology of these tumors was bland and the mitotic activity was low. Immunohistochemistry showed immunoreactivity for CK5/6 and p63, immunoreactivity for CD10 in the peripherally palisading cells and immunoreactivity for CK19 in the centrally located cells. The resected liver cystic tumors were originally diagnosed as "low-grade cystic ameloblastoma-like tumor in the liver" and suggested a possibility of metastasis. The patient was doing well clinically after the resection of her liver lesions. However, CT scan of the head and neck region at another hospital one year later showed an enhancing, expansile, well circumscribed mass in the right nasal cavity. Biopsy and resection of the nasal mass revealed an ameloblastoma invading the maxillary bone. The patient is doing well 2 months after her nasal surgery. To our knowledge, this is the first case of ameloblastoma manifested as liver metastases prior to the identification of a sinonasal primary.

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Section: Discussionmentioning

confidence: 45%

Section: Introductionmentioning

confidence: 99%

Multifocal Large Cystic Liver Metastasis of a Sinonasal Tract Ameloblastoma: An Unusual Clinical Presentation

Liu

2013

J Med Cases

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“…To the best of our knowledge, only two cases of extragnathic adamantinoma have been described affecting the rib as a primary disease [8,9]. Unlike the clinical presentation of these two previous reported cases -one with pleural and spine involvement, and the second with liver metastasesour patient only presented a solitary mass located to the 11th right rib.…”

Section: Discussionmentioning

confidence: 70%

“…In addition, a brief review about this uncommon bone tumor and a discussion of the recent findings regarding its osteofibrous dysplasia (OFD)-related histopathogenesis are presented. To the best of our knowledge, only two cases of primary EA originating from the rib have been previously reported in the English literature [8,9].…”

Section: Introductionmentioning

confidence: 99%

Primary Adamantinoma of the Rib. Unusual Presentation for a Bone Neoplasm of Uncertain Origin

Piña‐Oviedo

Valle

Padilla-Longoria

et al. 2008

Pathol. Oncol. Res.

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Adamantinomas are rare, low-grade malignant intra-osseous tumors composed of epithelial and mesenchymal elements, which show a marked predilection for the tibia and fibula of young adult male patients. Although cases of adamantinoma located to the axial skeleton have been reported either as recurrent or metastatic disease, only two cases of primary adamantinoma located to the thoracic wall have been previously described. In this study we present the clinical, radiological and histopathological features of a 24-year-old male with a slow growing, solid-cystic, painful mass, located to the right 11th rib, which was morphological and immunohistochemically diagnosed as a primary classic adamantinoma. Radiological studies showed a multiloculated lesion with a solid component. The patient underwent a whole surgical resection of the lesion. Histologically, multiple foci of epithelial cells with basaloid and squamous components were found intermixed within a fibrous stromal tissue. Immunohistochemical analysis demonstrated expression of cytokeratins, EMA, vimentin and other epithelial markers. Primary affection of the rib is an unusual feature of classic adamantinomas.

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“…Rare cases of adamantinomas of the olecranon, the ribs, the radius, the spine, the metatarsus, and the humerus also have been reported. [24][25][26][27][28][29][30][31]…”

Section: Educational Objectivesmentioning

confidence: 99%

Clinicopathological Features, Diagnosis, and Treatment of Adamantinoma of the Long Bones

Papagelopoulos¹,

Mavrogenis²,

Galanis³

et al. 2007

ORTHOPEDICS

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have no industry relationship to declare. The material presented at or in any Vindico Medical Education continuing education activity does not necessarily refl ect the views and opinions of Vindico Medical Education or Orthopedics. Neither Vindico Medical Education or Orthopedics, nor the faculty endorse or recommend any techniques, commercial products, or manufacturers. The faculty/authors may discuss the use of materials and/or products that have not yet been approved by the US Food and Drug Administration. All readers and continuing education participants should verify all information before treating patients or utilizing any product.

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Adamantinoma of the Rib Metastasizing to the Liver.

Cited by 18 publications

References 5 publications

Multifocal Large Cystic Liver Metastasis of a Sinonasal Tract Ameloblastoma: An Unusual Clinical Presentation

Multifocal Large Cystic Liver Metastasis of a Sinonasal Tract Ameloblastoma: An Unusual Clinical Presentation

Primary Adamantinoma of the Rib. Unusual Presentation for a Bone Neoplasm of Uncertain Origin

Clinicopathological Features, Diagnosis, and Treatment of Adamantinoma of the Long Bones

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